UBE2R2 and MUL1

Number of citations of the paper that reports this interaction (PubMedID 28763789)
37

Data Source:
BioGRID (pull down)

		UBE2R2	MUL1
Description		ubiquitin conjugating enzyme E2 R2	mitochondrial E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Cytosol	Mitochondrion Mitochondrial Outer Membrane Peroxisome Membrane Axon Neuronal Cell Body
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Positive Regulation Of Metabolic Process Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Positive Regulation Of Developmental Process Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Type 2 Mitophagy
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)	Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC	34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1
Entrez ID		54926	79594
HPRD ID		15602	07799
Ensembl ID		ENSG00000107341	ENSG00000090432
Uniprot IDs		Q712K3	Q969V5
PDB IDs		6NYO 8PQL 8Q7R 8R5H	6K2K 6M2C 6M2D
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Ubiquitin Protein Ligase Binding Transferase Activity Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization SCF Ubiquitin Ligase Complex Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Autoubiquitination Regulation Of Programmed Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Ubiquitin-protein Transferase Activity Proteolysis Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Nucleotide Binding ATP Binding Protein K11-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Transferase Activity Proteasomal Protein Catabolic Process Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Regulation Of Macroautophagy ISG15-protein Conjugation Cellular Response To Interferon-beta DNA Damage Response Protein K63-linked Ubiquitination Response To Interferon-beta Cellular Response To Stress Cytosol Response To Stress DNA Repair Positive Regulation Of Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Autophagy Nucleoplasm TORC1 Signaling Negative Regulation Of TORC1 Signaling Apoptotic Mitochondrial Changes DNA Metabolic Process Cellular Response To Nutrient Levels UBC13-MMS2 Complex Protein K6-linked Ubiquitination CGAS/STING Signaling Pathway TOR Signaling Ubiquitin Conjugating Enzyme Complex
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