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UBE2R2
Description
ubiquitin conjugating enzyme E2 R2
Image
GO Annotations
Cellular Component
Cytosol
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Ubiquitination
Protein K48-linked Ubiquitination
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Bipolar disorder (
20351715
)
Body mass index (
25673413
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31015462
)
Health literacy (
31250787
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Refractive error (
32231278
)
Interacting Genes
26 interacting genes:
APPBP2
ARHGDIA
ARIH2
BTRC
CBLC
CSNK2A1
CSNK2A2
CTNNB1
DTX3L
DZIP3
FBXW5
GSC2
INF2
ITCH
MAEA
MDM2
MEOX1
MUL1
PNPLA2
PRKN
RBX1
RNF113B
RNF31
SDCBP
UBA1
UBC
Entrez ID
54926
HPRD ID
15602
Ensembl ID
ENSG00000107341
Uniprot IDs
Q712K3
PDB IDs
6NYO
8PQL
8Q7R
8R5H
Enriched GO Terms of Interacting Partners
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Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Modification-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Protein Catabolic Process
Protein Modification Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis
Proteasomal Protein Catabolic Process
Catabolic Process
Positive Regulation Of Catabolic Process
Protein Metabolic Process
Protein K48-linked Ubiquitination
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Autophagy
Ubiquitin Protein Ligase Binding
Transferase Activity
Negative Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Regulation Of Macroautophagy
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Protein Targeting To Mitochondrion
Regulation Of Mitophagy
Regulation Of Protein Catabolic Process
Regulation Of Autophagy
Regulation Of Autophagy Of Mitochondrion
Regulation Of Post-translational Protein Modification
Regulation Of Cell Cycle
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
SCF Ubiquitin Ligase Complex
Negative Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Process
Protein Autoubiquitination
Regulation Of Programmed Cell Death
Protein K63-linked Ubiquitination
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Kinase CK2 Complex
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Mitochondrial Fission
Regulation Of Intracellular Signal Transduction
Tagcloud
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