UBE2R2 and CSNK2A2

Number of citations of the paper that reports this interaction (PubMedID 12037680)
0

Data Source:
HPRD (in vivo, in vitro)

		UBE2R2	CSNK2A2
Description		ubiquitin conjugating enzyme E2 R2	casein kinase 2 alpha 2
Image
GO Annotations	Cellular Component	Cytosol	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Protein Kinase CK2 Complex PcG Protein Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	Double-strand Break Repair Apoptotic Process DNA Damage Response Spermatogenesis Wnt Signaling Pathway Cerebral Cortex Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Liver Regeneration Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity KEAP1-NFE2L2 pathway Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins SPOP-mediated proteasomal degradation of PD-L1(CD274) Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs			[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid Fostamatinib
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)	Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)
Interacting Genes		26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC	104 interacting genes: ABCA1 ACACA ADH1A AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CEBPA CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERCC6 ERH FGF1 FGF2 FKBP3 FOS GRIN2A GRIN2B GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PICK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF670 ZNHIT3
Entrez ID		54926	1459
HPRD ID		15602	00279
Ensembl ID		ENSG00000107341	ENSG00000070770
Uniprot IDs		Q712K3	P19784
PDB IDs		6NYO 8PQL 8Q7R 8R5H	3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6L20 6QY8 6QY9 6TE2 6TEW 6TGU 7A1B 7A1Z 7A22 7A2H 7AT9 7ATV 7XYH 8Q77 8Q9S 8QBU 8QCD 8QCG 8QF1
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Ubiquitin Protein Ligase Binding Transferase Activity Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization SCF Ubiquitin Ligase Complex Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Autoubiquitination Regulation Of Programmed Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction	Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Enzyme Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Response To Alcohol Regulation Of Signal Transduction Regulation Of Metabolic Process Macromolecule Metabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Stress Response To Alkaloid Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of RNA Metabolic Process
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