UBE2R2 and MAEA

Number of citations of the paper that reports this interaction (PubMedID 29911972)
52

Data Source:
BioGRID (enzymatic study)

		UBE2R2	MAEA
Description		ubiquitin conjugating enzyme E2 R2	macrophage erythroblast attacher, E3 ubiquitin ligase
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GO Annotations	Cellular Component	Cytosol	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Nuclear Matrix GID Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Actin Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	Cytoskeleton Organization Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Myeloid Cell Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Erythrocyte Development Enucleate Erythrocyte Development Cell Division
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of pyruvate metabolism
Drugs			Tetrachlorodecaoxide
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)	Fasting glucose ( 34059833) Obesity-related traits ( 23251661) Pulse pressure ( 30224653) Type 2 diabetes ( 22158537 23945395 26818947 28869590 30297969 30718926 32499647)
Interacting Genes		26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC	6 interacting genes: GID4 GSK3A MYOC UBE2D3 UBE2H UBE2R2
Entrez ID		54926	10296
HPRD ID		15602	08427
Ensembl ID		ENSG00000107341	ENSG00000090316
Uniprot IDs		Q712K3	B3KRN7 B4DJP8 B4DQT1 B4DVN3 D6RIB6 Q7L5Y9
PDB IDs		6NYO 8PQL 8Q7R 8R5H	8PJN
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Ubiquitin Protein Ligase Binding Transferase Activity Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization SCF Ubiquitin Ligase Complex Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Autoubiquitination Regulation Of Programmed Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Proteolysis Involved In Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Proteolysis Proteasomal Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Ubiquitin-protein Transferase Activity Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Polyubiquitination Protein K11-linked Ubiquitination Catabolic Process Regulation Of Protein Targeting To Mitochondrion Protein Monoubiquitination Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of UDP-glucose Catabolic Process Skeletal Muscle Hypertrophy ATP Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Cell-substrate Adhesion Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Nucleotide Binding Regulation Of Glycogen (starch) Synthase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Clustering Of Voltage-gated Sodium Channels Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Post-translational Protein Modification Regulation Of Cell-substrate Adhesion Cellular Response To Interleukin-3 Myosin Light Chain Binding Skeletal Muscle Adaptation Proximal Dendrite Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Wnt Signaling Pathway
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