UBE2R2 and RNF113B

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		UBE2R2	RNF113B
Description		ubiquitin conjugating enzyme E2 R2	ring finger protein 113B
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GO Annotations	Cellular Component	Cytosol	U2-type Spliceosomal Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination	SnoRNA Splicing
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 25673413) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278)	Clozapine-induced agranulocytosis ( 25187353) Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 DTX3L DZIP3 FBXW5 GSC2 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 SDCBP UBA1 UBC	4 interacting genes: UBE2H UBE2L3 UBE2R2 UBE2U
Entrez ID		54926	140432
HPRD ID		15602	15745
Ensembl ID		ENSG00000107341	ENSG00000139797
Uniprot IDs		Q712K3	Q8IZP6
PDB IDs		6NYO 8PQL 8Q7R 8R5H	2CSY
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy Ubiquitin Protein Ligase Binding Transferase Activity Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Post-translational Protein Modification Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization SCF Ubiquitin Ligase Complex Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Protein Autoubiquitination Regulation Of Programmed Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein K11-linked Ubiquitination ATP Binding Protein Modification Process Nucleotide Binding Transferase Activity Catabolic Process Protein K48-linked Ubiquitination Protein Metabolic Process HULC Complex Ubiquitin-protein Transferase Activator Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Protein Targeting To Mitochondrion Cellular Response To Glucocorticoid Stimulus Protein Monoubiquitination Cellular Response To Corticosteroid Stimulus
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