WHSC1L1 and SPAG8

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		WHSC1L1	SPAG8
Gene Name		Wolf-Hirschhorn syndrome candidate 1-like 1	sperm associated antigen 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Acrosomal Vesicle Nucleus Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K4 Specific) Histone Methyltransferase Activity (H3-K27 Specific)	Molecular_function Microtubule Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Histone Methylation Negative Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K27 Methylation	Biological_process Positive Regulation Of Protein Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Schizophrenia ( 22037555)
Protein-Protein Interactions		17 interactors: CBX3 CBX5 DAXX DOCK7 ETV3 GLYR1 H3F3C HIST1H1A HOXC4 MLLT6 MNDA SEPT6 SLU7 SPAG8 STAC3 UBE2I ZNF557	15 interactors: CARM1 CSTF2 DTX2 JMJD4 KDM3B KLHL32 NEDD4L PITX1 PRMT1 PRMT2 PRMT5 RAN SNRPC UBQLN4 WHSC1L1
Entrez ID		54904	26206
HPRD ID		06155	12039
Ensembl ID		ENSG00000147548	ENSG00000137098
Uniprot IDs		B7ZL11 Q9BZ95	Q99932
PDB IDs		2DAQ 4GND 4GNE 4GNF 4GNG
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Cell Division Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Viral Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Establishment Of Neuroblast Polarity Cytokinesis Nucleosome Assembly MRNA 3'-splice Site Recognition Transcription, DNA-templated Chromatin Assembly RNA Metabolic Process RNA Biosynthetic Process Regulation Of Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Gene Expression Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Remodeling DNA Packaging Nucleobase-containing Compound Metabolic Process	Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Protein Methylation Chromatin Modification Chromatin Organization Histone Modification Methylation Chromosome Organization Gene Expression Histone H4-R3 Methylation Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Peptidyl-amino Acid Modification Regulation Of RNA Metabolic Process RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Spliceosomal SnRNP Assembly Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nitrogen Compound Metabolic Process Organelle Organization Histone H3-R17 Methylation Cellular Protein Modification Process Ribonucleoprotein Complex Biogenesis Intracellular Steroid Hormone Receptor Signaling Pathway RNA Splicing Regulation Of Metabolic Process Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Positive Regulation Of Caveolin-mediated Endocytosis Cellular Macromolecule Biosynthetic Process MRNA Processing Macromolecule Biosynthetic Process Ribosomal Small Subunit Export From Nucleus Branchiomeric Skeletal Muscle Development MRNA 5'-splice Site Recognition Regulation Of Growth Plate Cartilage Chondrocyte Proliferation
Tagcloud ?		aside c5hch cys dimethylase fifth h3k36 h3k4 h3k9 h3k9me0 h3k9me3 homeodomain k9 k9me3 methyltransferases mmset module mono nonredundant nsd nsd1 nsd2 nsd3 phd phd5 shed trimethylated unmethylated unmodified	azoospermia bonferroni cgtg chinese conferred correction crem haplotype idiopathic iplex kif17b maturation noa nonobstructive played polymorphisms protective rs1148247 rs11592356 rs2295415 rs22954152 rs4934540 sequenom seventeen snps spermatogenesis tag tatg variants
Tagcloud (Difference) ?		aside c5hch cys dimethylase fifth h3k36 h3k4 h3k9 h3k9me0 h3k9me3 homeodomain k9 k9me3 methyltransferases mmset module mono nonredundant nsd nsd1 nsd2 nsd3 phd phd5 shed trimethylated unmethylated unmodified	azoospermia bonferroni cgtg chinese conferred correction crem haplotype idiopathic iplex kif17b maturation noa nonobstructive played polymorphisms protective rs1148247 rs11592356 rs2295415 rs22954152 rs4934540 sequenom seventeen snps spermatogenesis tag tatg variants
Tagcloud (Intersection) ?