NSD3 and PAX2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		NSD3	PAX2
Description		nuclear receptor binding SET domain protein 3	paired box 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome	Chromatin Nucleus Nucleoplasm Microtubule Organizing Center Protein-containing Complex Protein-DNA Complex Centriolar Satellite
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3K27 Methyltransferase Activity Transcription Regulator Activator Activity Histone H3 Methyltransferase Activity Histone H3K4 Dimethyltransferase Activity Histone H3K27 Trimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of DNA-templated Transcription	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Sensory Organ Development Mesodermal Cell Fate Specification Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Cell Differentiation Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Mesenchymal To Epithelial Transition Optic Chiasma Development Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Nephric Duct Formation Ureter Development Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cochlea Development Cochlea Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation
Pathways		PKMTs methylate histone lysines	Formation of intermediate mesoderm Formation of the nephric duct Formation of the ureteric bud
Drugs
Diseases			Renal coloboma syndrome (RCS); Papillorenal syndrome
GWAS			Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30679032) Alzheimer's disease ( 20061627) Bitter alcoholic beverage consumption ( 31046077) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Diastolic blood pressure ( 27841878) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Systolic blood pressure ( 30578418 28135244 27841878)
Interacting Genes		41 interacting genes: AKT1 ATM BCAR3 CASP8 CBLC CBX3 CBX5 CDKN2A CHEK2 DAXX DOCK7 ESR1 ETV3 FGFR4 GLIS2 GLYR1 H1-1 H3-5 H3C1 H4C1 HOXC4 MLLT6 MNDA NFIC PAX2 PPM1D RB1CC1 SEPTIN6 SLU7 SOX3 SOX4 SPAG8 STAC3 TCF3 TEAD2 TERT TGFB1 TRIM55 TRIM63 UBE2I ZNF557	28 interacting genes: BBS1 BBS2 BBS4 BBS7 BEX1 BLID GLCE HNF1B ID2 IL13RA2 KLK6 KLK9 MAPK8 MAPK8IP1 MRC2 NFIC NFIX NSD3 PAXIP1 PRDM14 RASL10B RB1 SFRP2 SNAI1 TRIM25 VHL VPS45 WT1
Entrez ID		54904	5076
HPRD ID		06155	01330
Ensembl ID		ENSG00000147548	ENSG00000075891
Uniprot IDs		Q9BZ95	A0A9L9PXU6 A0A9L9PYK3 Q02962 Q5SZP1
PDB IDs		2DAQ 2NCZ 2ND1 4GND 4GNE 4GNF 4GNG 4RXJ 5UPD 6CEN 6G24 6G25 6G27 6G29 6G2B 6G2C 6G2E 6G2F 6G2O 6G3P 6G3T 7CRP 7CRQ 7CRR 7JYN
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Replicative Senescence Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process PML Body Euchromatin Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Chromatin Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Protein K63-linked Ubiquitination Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Protein Localization To Nucleus Cell Differentiation Chromosome, Telomeric Region Cellular Developmental Process Chromatin Remodeling DNA-binding Transcription Factor Activity Pexophagy Negative Regulation Of B Cell Proliferation	BBSome Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Metabolic Process Regulation Of Cilium Movement Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Striatum Development Ciliary Membrane Regulation Of Cilium Beat Frequency Fat Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Brain Morphogenesis Digestive Tract Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Melanosome Transport Positive Regulation Of Biosynthetic Process Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Tube Morphogenesis Negative Regulation Of RNA Metabolic Process Pigment Granule Localization Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Epithelial Tube Morphogenesis
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