CDKN1C and CCNE2

Number of citations of the paper that reports this interaction (PubMedID 9840943)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDKN1C	CCNE2
Description		cyclin dependent kinase inhibitor 1C	cyclin E2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Kidney Development Placenta Development Regulation Of Exit From Mitosis Myeloid Cell Differentiation Adrenal Gland Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Multicellular Organism Growth Negative Regulation Of Phosphorylation Neuron Maturation Camera-type Eye Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Digestive System Development Uterus Development Embryonic Placenta Morphogenesis Genomic Imprinting Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Cyclin-dependent Protein Kinase Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance DNA Replication Initiation Homologous Chromosome Pairing At Meiosis Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Beckwith-Wiedemann syndrome Adrenal carcinoma	Laryngeal cancer Gastric cancer
GWAS		Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061) Type 1 diabetes ( 34012112)	Keratoconus ( 33649486)
Interacting Genes		10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2	12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		1028	9134
HPRD ID		02913	04801
Ensembl ID		ENSG00000129757	ENSG00000175305
Uniprot IDs		A0A2R8YFP9 P49918	O96020
PDB IDs			8HN9
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Hormone Positive Regulation Of Deoxyribonuclease Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Oxygen-containing Compound Striated Muscle Cell Differentiation Transcription Regulator Complex Positive Regulation Of Cell Cycle Process Cellular Response To Ether Response To Peptide Hormone Kinase Binding Muscle Cell Differentiation Positive Regulation Of Cell Cycle Response To Oxygen Levels Cellular Response To Hormone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Enzyme Binding Response To Ether Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Response To Insulin Positive Regulation Of Developmental Growth Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Neuron Maturation Cellular Response To Peptide Hormone Stimulus Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Starvation Myoblast Differentiation Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Catalytic Activity Response To Ketone Regulation Of Cell Cycle Chromatin Response To Starvation Macromolecule Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Male Germ Cell Nucleus Regulation Of Protein Modification Process Cellular Response To Nutrient Levels	Cyclin Binding Regulation Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of DNA Replication Ubiquitin Protein Ligase Binding Molecular Function Inhibitor Activity Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Kinase Inhibitor Activity Positive Regulation Of Protein Catabolic Process Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Protein Tag Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Exit From Mitosis Negative Regulation Of Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Population Proliferation Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Binding DNA Damage Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Molecular Function Activator Activity Negative Regulation Of Epithelial Cell Proliferation
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