CDKN1C and CCNE2

Number of citations of the paper that reports this interaction (PMID 9840943)
26

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDKN1C	CCNE2
Gene Name		cyclin-dependent kinase inhibitor 1C (p57, Kip2)	cyclin E2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Kidney Development Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Aging Myeloid Cell Differentiation Adrenal Gland Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Multicellular Organism Growth Negative Regulation Of Phosphorylation Neuron Maturation Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Digestive System Development Uterus Development Embryonic Placenta Morphogenesis Genetic Imprinting Negative Regulation Of Protein Serine/threonine Kinase Activity	Cell Cycle Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Cell Division
Pathways			DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		11 interactors: AKT1 CCND1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2	11 interactors: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		1028	9134
HPRD ID		02913	04801
Ensembl ID		ENSG00000129757	ENSG00000175305
Uniprot IDs		P49918	O96020 Q8WUE3
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle Response To Extracellular Stimulus Regulation Of Catalytic Activity Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Response To UV-A Positive Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To Lipid Regulation Of Cell Size Response To Organic Cyclic Compound Cell Division Response To Hormone Positive Regulation Of Cellular Metabolic Process Response To Inorganic Substance Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Response To Steroid Hormone Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Process Chromosome Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Neuron Maturation System Development Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Organ Development Cellular Response To Extracellular Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Growth Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Organelle Organization Cellular Protein Modification Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Protein Catabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Cellular Protein Modification Process Regulation Of Kinase Activity Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Arrest Negative Regulation Of Epithelial Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Cell Cycle Arrest Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	amplification amplifications aneuploidy breast carcinomas clinicopathologic coexist december ductal fish foci infiltrating january ki microarray multi myc often overlapping quantitative relationship roles selected showing situ sixty strong unique
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	amplification amplifications aneuploidy breast carcinomas clinicopathologic coexist december ductal fish foci infiltrating january ki microarray multi myc often overlapping quantitative relationship roles selected showing situ sixty strong unique
Tagcloud (Intersection) ?