CDKN1C and LIMK1

Number of citations of the paper that reports this interaction (PMID 14530263)
28

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CDKN1C	LIMK1
Gene Name		cyclin-dependent kinase inhibitor 1C (p57, Kip2)	LIM domain kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Cytoplasm Cytosol Focal Adhesion Neuron Projection
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Heat Shock Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Kidney Development Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Aging Myeloid Cell Differentiation Adrenal Gland Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Multicellular Organism Growth Negative Regulation Of Phosphorylation Neuron Maturation Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Digestive System Development Uterus Development Embryonic Placenta Morphogenesis Genetic Imprinting Negative Regulation Of Protein Serine/threonine Kinase Activity	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Positive Regulation Of Axon Extension Ephrin Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways			EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema3A PAK dependent Axon repulsion Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS		Calcium levels ( 20705733)
Protein-Protein Interactions		11 interactors: AKT1 CCND1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2	25 interactors: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 HIST1H1A LATS1 LIMK2 MAPK14 MAPKAPK2 MBP NRG1 PAK1 PAK2 PAK4 PXN RLIM ROCK1 SRPK1 SSH3 YWHAZ
Entrez ID		1028	3984
HPRD ID		02913	03210
Ensembl ID		ENSG00000129757	ENSG00000106683
Uniprot IDs		P49918	P53667
PDB IDs			3S95
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle Response To Extracellular Stimulus Regulation Of Catalytic Activity Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Response To UV-A Positive Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Mitotic Cell Cycle Response To Lipid Regulation Of Cell Size Response To Organic Cyclic Compound Cell Division Response To Hormone Positive Regulation Of Cellular Metabolic Process Response To Inorganic Substance Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Response To Steroid Hormone Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Process Chromosome Organization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Neuron Maturation System Development Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Organ Development Cellular Response To Extracellular Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Growth Positive Regulation Of Cell Cycle Process Striated Muscle Cell Differentiation Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Organelle Organization Cellular Protein Modification Process	Phosphorylation Cellular Protein Modification Process Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Signal Transduction By Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Protein Metabolic Process Platelet Activation Signaling Regulation Of Kinase Activity Cell Communication Response To External Stimulus Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction Cell Differentiation Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Organelle Organization Locomotion Immune Response Neurogenesis Apoptotic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Signaling Defense Response Programmed Cell Death Organelle Organization Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Difference) ?		2xglucocorticoid 2xgre agonism agonists beas bronchial budesonide ciclesonide combat dexamethasone dusp1 fluticasone formoterol furoate glucocorticoid glucocorticoids gre gsk9027 gw870086x ikk2 nr3c1 phosphoinositide propionate reporter rgs2 ru24858 suboptimal tsc22d3 viii	alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Intersection) ?