CDKN1C and LIMK1

Number of citations: 0 (PubMedID 14530263)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		CDKN1C	LIMK1
Name		cyclin dependent kinase inhibitor 1C	LIM domain kinase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Cell Junction Cell Projection Neuron Projection Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin Ligase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Kidney Development Placenta Development Regulation Of Exit From Mitosis Myeloid Cell Differentiation Adrenal Gland Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Multicellular Organism Growth Negative Regulation Of Phosphorylation Neuron Maturation Camera-type Eye Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Digestive System Development Uterus Development Embryonic Placenta Morphogenesis Genomic Imprinting Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Cyclin-dependent Protein Kinase Activity	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stress Fiber Assembly Positive Regulation Of Axon Extension Axon Extension Positive Regulation Of Stress Fiber Assembly
Pathways		Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs		None	Dabrafenib Fostamatinib
Diseases		Beckwith-Wiedemann syndrome Adrenal carcinoma	None
GWAS		Birth weight ( 31043758 ) Calcium levels ( 20705733 ) Malaria ( 31844061 ) Type 1 diabetes ( 34012112 )	Pulse pressure ( 30224653 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Youthful appearance (self-reported) ( 32339537 )
Novel Interactors		1 novel interactors: SLC2A1	2 novel interactors: C5 SELENOS
Interacting Genes		10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2	31 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 DSCAM FBXO7 H1-1 HUNK LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ
Entrez ID		1028	3984
HPRD ID		02913	03210
Ensembl ID		ENSG00000129757	ENSG00000106683
Uniprot IDs		A0A2R8YFP9 P49918	P53667
PDB IDs		Not available	3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU 7B8W 8AAU
GO Terms Enriched among Interactors		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Hormone Positive Regulation Of Deoxyribonuclease Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Response To Oxygen-containing Compound Striated Muscle Cell Differentiation Transcription Regulator Complex Positive Regulation Of Cell Cycle Process Cellular Response To Ether Response To Peptide Hormone Kinase Binding Muscle Cell Differentiation Positive Regulation Of Cell Cycle Response To Oxygen Levels Cellular Response To Hormone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Enzyme Binding Response To Ether Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Response To Insulin Positive Regulation Of Developmental Growth Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Neuron Maturation Cellular Response To Peptide Hormone Stimulus Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Starvation Myoblast Differentiation Regulation Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Catalytic Activity Response To Ketone Regulation Of Cell Cycle Chromatin Response To Starvation Macromolecule Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Growth Male Germ Cell Nucleus Regulation Of Protein Modification Process Cellular Response To Nutrient Levels	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Protein Kinase Activity Regulation Of Cellular Component Organization Kinase Activity Intracellular Signal Transduction Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling ATP Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Nucleotide Binding Actin Cytoskeleton Organization Regulation Of Interleukin-6 Production Regulation Of Protein Localization To Nucleus Regulation Of Cytoskeleton Organization Actin Filament-based Process Cellular Response To Starvation Transferase Activity Regulation Of Growth Response To Growth Factor Negative Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Nutrient Levels Dendritic Spine Development Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Projection Organization Angiotensin Receptor Binding Protein Phosphorylation Regulation Of Receptor-mediated Endocytosis Response To Starvation Positive Regulation Of Cellular Component Biogenesis Phosphorylation Positive Regulation Of Growth Regulation Of Immune Response Regulation Of Organelle Organization Cellular Response To Nutrient Levels Regulation Of Phosphorus Metabolic Process Clathrin-coated Pit