KCTD9 and AQP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KCTD9	AQP1
Gene Name		potassium channel tetramerization domain containing 9	aquaporin 1 (Colton blood group)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Axon Terminus Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function		Intracellular CGMP Activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Glycerol Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Ephrin Receptor Binding
	Biological Process	Protein Homooligomerization	Renal Water Homeostasis Glomerular Filtration Renal Water Transport CGMP Biosynthetic Process Potassium Ion Transport Water Transport Cell Volume Homeostasis Cellular Water Homeostasis Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Epithelial Cell Migration Carbon Dioxide Transport Ammonium Transport Bicarbonate Transport Glycerol Transport Sensory Perception Of Pain Cellular Homeostasis Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Secretory Granule Organization Cellular Response To Stress Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Wound Healing Odontogenesis Response To Drug Hyperosmotic Salinity Response Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Estrogen Lipid Digestion Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Multicellular Organismal Water Homeostasis Corticotropin Secretion Transmembrane Transport Renal Water Absorption Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Ammonium Transmembrane Transport Maintenance Of Symbiont-containing Vacuole By Host Cation Transmembrane Transport
Pathways			O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Erythrocytes take up oxygen and release carbon dioxide Aquaporin-mediated transport
Drugs			Acetazolamide
Diseases
GWAS			Nephrolithiasis ( 22396660)
Protein-Protein Interactions		29 interactors: AQP1 CARD9 CBX8 CCDC33 CRADD CUL3 EHHADH FAM124B FAM208B GEM GORASP2 KRT40 LONRF1 MAD2L2 MVP NUP35 PNKD PPP1R16B PPP1R18 PSMA1 PSMB2 RBPMS SDCBP SKP1 STX11 SYT6 TRIM27 TRIM32 TRIM42	42 interactors: ADAMTSL4 CCDC136 CCDC36 CCDC57 CCDC85B CEP44 CRTAC1 CSRNP1 EFEMP2 EPHB2 FOS FSD2 IKZF2 IKZF3 KCTD17 KCTD9 KIAA1958 KRT31 KRT33B KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 KRTAP4-2 KRTAP9-2 MDFI MID2 MTUS2 NBPF22P NOTCH2NL PICK1 RGS17 RGS20 RIMBP3 SIAH1 SPRY2 TCF4 TNK2 TRAF1 TRAF2 TRIM23 TRIP6
Entrez ID		54793	358
HPRD ID		13772	00140
Ensembl ID		ENSG00000104756	ENSG00000240583
Uniprot IDs		B4DPW0 Q7L273	B4DPF5 B4E3E3 P29972
PDB IDs			1FQY 1H6I 1IH5
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Process Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signaling Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Catalytic Activity Cell Communication Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Regulation Of Phosphorus Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint	Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Binding Developmental Process Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Dendritic Spine Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Axonal Fasciculation Embryonic Organ Morphogenesis Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Binding Cell Differentiation Regulation Of Cellular Process Face Morphogenesis Neuron Recognition Regulation Of Apoptotic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Head Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Signaling Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Communication Negative Regulation Of Signaling Face Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Cellular Response To Extracellular Stimulus Embryonic Organ Development I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Fat Cell Differentiation Body Morphogenesis DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Termination Of Signal Transduction Toll-like Receptor 3 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?			2cl absorption acclimation bumetanide circuit cl cotransporter eel exchanger gn governed guanylin hco3 intestine isc mi ncc nccbeta nkcc nkcc2beta nullified player remainder seawater slc26a6 teleost transporters versa vice
Tagcloud (Difference) ?			2cl absorption acclimation bumetanide circuit cl cotransporter eel exchanger gn governed guanylin hco3 intestine isc mi ncc nccbeta nkcc nkcc2beta nullified player remainder seawater slc26a6 teleost transporters versa vice
Tagcloud (Intersection) ?