ATP12A and GNAI3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ATP12A	GNAI3
Name		ATPase H+/K+ transporting non-gastric alpha2 subunit	G protein subunit alpha i3
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Potassium:proton Exchanging ATPase Complex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cation-transporting ATPase Complex Plasma Membrane Protein Complex	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome
	Molecular Function	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity ATP Binding P-type Potassium Transmembrane Transporter Activity P-type Potassium:proton Transporter Activity ATP Hydrolysis Activity Metal Ion Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of PH Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Potassium Ion Homeostasis Proton Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division
Pathways		Ion transport by P-type ATPases	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
GWAS		Diastolic blood pressure ( 30224653 ) Meconium ileus in cystic fibrosis ( 30807572 ) Obesity-related traits ( 23251661 )	Childhood body mass index ( 33045005 ) Major depressive disorder ( 20125088 )
Interacting Genes		3 interacting genes: GNAI3 NPY PPIB	45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR
Entrez ID		479	2773
HPRD ID		01667	00765
Ensembl ID		ENSG00000075673	ENSG00000065135
Uniprot IDs		B4E0R9 P54707	P08754
PDB IDs		Not available	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL
GO Terms Enriched among Interactors		G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Y Receptor Binding Monocyte Activation Positive Regulation Of Eating Behavior Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Eating Behavior Positive Regulation Of Response To Food Short-day Photoperiodism Regulation Of Nerve Growth Factor Production Positive Regulation Of Dopamine Metabolic Process Antifungal Humoral Response Positive Regulation Of Appetite Synaptic Signaling Via Neuropeptide Intestinal Epithelial Cell Differentiation Adult Feeding Behavior Positive Regulation Of Feeding Behavior Cyclosporin A Binding Endoplasmic Reticulum Chaperone Complex Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Response To Yeast Guanyl Nucleotide Binding Regulation Of Response To Food Regulation Of Acute Inflammatory Response To Antigenic Stimulus G-protein Beta/gamma-subunit Complex Binding GTP Metabolic Process Regulation Of Dopamine Metabolic Process Neuronal Dense Core Vesicle Smooth Endoplasmic Reticulum RNA Polymerase Binding Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Perinuclear Region Of Cytoplasm Positive Regulation Of Behavior Neuropeptide Hormone Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Heterotrimeric G-protein Complex Positive Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Nutrient Levels Peptidyl-prolyl Cis-trans Isomerase Activity Host-mediated Activation Of Viral Process Terminal Bouton Positive Regulation Of Nitric Oxide Metabolic Process Calcium Channel Regulator Activity Central Nervous System Neuron Development	G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior