HSPA6 and CISH

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HSPA6	CISH
Gene Name		heat shock 70kDa protein 6 (HSP70B)	cytokine inducible SH2-containing protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centriole Cytosol COP9 Signalosome Extracellular Vesicular Exosome Blood Microparticle	Cellular_component Cytoplasm Cytosol Plasma Membrane
	Molecular Function	ATP Binding Enzyme Binding Heat Shock Protein Binding ATPase Activity, Coupled Unfolded Protein Binding	Molecular_function Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways			Cytokine Signaling in Immune system Growth hormone receptor signaling
Drugs
Diseases
GWAS		Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		5 interactors: ADCK5 CISH CYP4F12 DNAJB4 TERF1	18 interactors: CSF2RB CSF3R EGFR EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		3310	1154
HPRD ID		00775	03897
Ensembl ID		ENSG00000173110	ENSG00000114737
Uniprot IDs		P17066	Q9NSE2
PDB IDs		3FE1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Pressure Natriuresis Age-dependent Telomere Shortening Vitamin K Biosynthetic Process Telomere Maintenance Via Telomere Shortening Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Vitamin K Metabolic Process Negative Regulation Of Transferase Activity Long-chain Fatty Acid Catabolic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Epoxygenase P450 Pathway Regulation Of Telomere Maintenance RNA-dependent DNA Replication JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of JAK-STAT Cascade Negative Regulation Of DNA Biosynthetic Process Sodium Ion Homeostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Renal Water Homeostasis Regulation Of Microtubule Polymerization Telomere Maintenance Via Telomere Lengthening Very Long-chain Fatty Acid Metabolic Process Leukotriene Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Quinone Metabolic Process Drug Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Spindle Checkpoint Response To Growth Hormone Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA Replication Negative Regulation Of Catalytic Activity Multicellular Organismal Water Homeostasis	Cellular Response To Organic Substance Response To Organic Substance Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Cytokine Stimulus Cellular Response To Stimulus Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Histone H3-T6 Phosphorylation Erythropoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Activation Of JAK2 Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Response To Growth Factor Chemotaxis Negative Regulation Of Cell Death Cellular Response To Erythropoietin Regulation Of MAPK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa1a hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability
Tagcloud (Difference) ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa1a hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability
Tagcloud (Intersection) ?