HSPA6 and DNAJB4

Number of citations of the paper that reports this interaction (PMID 21231916)
25

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		HSPA6	DNAJB4
Gene Name		heat shock 70kDa protein 6 (HSP70B)	DnaJ (Hsp40) homolog, subfamily B, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centriole Cytosol COP9 Signalosome Extracellular Vesicular Exosome Blood Microparticle	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	ATP Binding Enzyme Binding Heat Shock Protein Binding ATPase Activity, Coupled Unfolded Protein Binding	Protein Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation	Protein Folding Response To Unfolded Protein Response To Heat
Pathways
Drugs
Diseases
GWAS		Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		5 interactors: ADCK5 CISH CYP4F12 DNAJB4 TERF1	8 interactors: HSPA6 MDM2 OPRM1 PABPN1 POLR1D SMAD3 TBL1X TBPL2
Entrez ID		3310	11080
HPRD ID		00775	07486
Ensembl ID		ENSG00000173110
Uniprot IDs		P17066	B4DNN2 Q9UDY4
PDB IDs		3FE1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Pressure Natriuresis Age-dependent Telomere Shortening Vitamin K Biosynthetic Process Telomere Maintenance Via Telomere Shortening Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Vitamin K Metabolic Process Negative Regulation Of Transferase Activity Long-chain Fatty Acid Catabolic Process Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Epoxygenase P450 Pathway Regulation Of Telomere Maintenance RNA-dependent DNA Replication JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of JAK-STAT Cascade Negative Regulation Of DNA Biosynthetic Process Sodium Ion Homeostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Renal Water Homeostasis Regulation Of Microtubule Polymerization Telomere Maintenance Via Telomere Lengthening Very Long-chain Fatty Acid Metabolic Process Leukotriene Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Quinone Metabolic Process Drug Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Spindle Checkpoint Response To Growth Hormone Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Regulation Of DNA Biosynthetic Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA Replication Negative Regulation Of Catalytic Activity Multicellular Organismal Water Homeostasis	Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Initiation Cellular Response To Alkaloid Response To Morphine Response To Cocaine Negative Regulation Of Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription, DNA-templated DNA-templated Transcription, Termination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Wnt Protein Secretion Positive Regulation Of Transforming Growth Factor Beta3 Production Cellular Response To UV-C Cellular Response To Vitamin B1 Transcription, DNA-templated Response To Ammonium Ion RNA Biosynthetic Process Immune Response Interaction With Host Positive Regulation Of Nucleocytoplasmic Transport Viral Process Modification By Virus Of Host MRNA Processing Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Growth Factor Regulation Of Protein Transport Regulation Of Protein Stability Evasion Or Tolerance Of Host Defenses By Virus Response To Alkaloid Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To Morphine Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Appetite Response To Vitamin B1 Response To Ether Cellular Response To Isoquinoline Alkaloid Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Primary MiRNA Processing
Tagcloud ?		chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa1a hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	affinities anthanogene bag bag1 bag2 bag3 bcl2 chaperones cochaperones combinations combinatorial compete competed dnaja1 dnaja2 generate hierarchy hsp105 hsp70 hsp72 hspa1a mammals nef nefs permutations refolding stoichiometry unrelated
Tagcloud (Difference) ?		chaperone complement defective enlarged experimentally heat hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1	affinities anthanogene bag bag1 bag2 bag3 bcl2 chaperones cochaperones combinations combinatorial compete competed dnaja2 generate hierarchy hsp105 hsp70 hsp72 mammals nef nefs permutations refolding stoichiometry unrelated
Tagcloud (Intersection) ?		dnaja1 dnajb1 hspa1a