HSPA6 and COMMD6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSPA6	COMMD6
Description		heat shock protein family A (Hsp70) member 6	COMM domain containing 6
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding NF-kappaB Binding
	Biological Process	Protein Folding Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation	Signal Transduction Negative Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Regulation of HSF1-mediated heat shock response Neutrophil degranulation	Neddylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233 28067908) Offspring birth weight ( 31043758) Ulcerative colitis ( 21297633 28067908)	Appendicular lean mass ( 33097823) Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483) Red blood cell count ( 29403010)
Interacting Genes		18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 SNCA TERF1 WEE2-AS1	3 interacting genes: COMMD1 HSPA6 USP40
Entrez ID		3310	170622
HPRD ID		00775	13084
Ensembl ID		ENSG00000173110	ENSG00000188243
Uniprot IDs		A0A384NKX5 B3KSM6 P17066	Q7Z4G1
PDB IDs		3FE1	8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Exocytosis Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Protein Stability Positive Regulation Of Organelle Organization Protein Sequestering Activity Intracellular Membrane-bounded Organelle Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of MRNA Modification Positive Regulation Of Triglyceride Transport Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cellular Component Organization	L-allo-threonine Aldolase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Formate Biosynthetic Process Positive Regulation Of Endosome To Plasma Membrane Protein Transport Cellular Heat Acclimation Glycine Biosynthetic Process Post-translational Protein Modification BRISC Complex Formate Metabolic Process L-serine Biosynthetic Process Regulation Of Protein Ubiquitination Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Post-translational Protein Modification Branchiomotor Neuron Axon Guidance Microtubule Cytoskeleton Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Sodium Ion Transmembrane Transport Tetrahydrofolate Interconversion Regulation Of Synaptic Assembly At Neuromuscular Junction Plasma Membrane To Endosome Transport Glycine Metabolic Process Response To Type I Interferon Intracellular Organelle Lumen Amino Acid Binding Regulation Of Axon Guidance Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Protein Localization To Cell Surface L-serine Metabolic Process Negative Regulation Of Sodium Ion Transport Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Low-density Lipoprotein Particle Clearance Tetrahydrofolate Metabolic Process Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Mitochondrial Translation Regulation Of Endocytic Recycling Regulation Of Protein Metabolic Process Regulation Of Oxidative Phosphorylation
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