PAFAH1B2 and CCT3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PAFAH1B2	CCT3
Description		platelet activating factor acetylhydrolase 1b catalytic subunit 2	chaperonin containing TCP1 subunit 3
Image
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Nucleolus Cytoplasm Cytosol Plasma Membrane 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Lipid Metabolic Process Spermatogenesis Lipid Catabolic Process Positive Regulation Of Macroautophagy	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 23696881) HDL cholesterol ( 24507774) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Systolic blood pressure ( 30578418)	Basophil count ( 32888494) Glycated hemoglobin levels ( 24647736) Household income (MTAG) ( 31844048) Mean corpuscular hemoglobin concentration ( 20139978) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738) Walking pace ( 33128006)
Interacting Genes		19 interacting genes: ACIN1 ASF1A CCT3 CLVS2 CRK PAFAH1B1 PAFAH1B3 PINX1 PPP1R12C PRKN REXO1 RPLP0 SLA SNUPN STAT3 TIMM50 TRIM55 TRIM63 ZFP36L1	26 interacting genes: BUD31 CEBPA DEPDC5 EIF2B2 ERBB2 FANCA GEMIN4 HNRNPA0 HSPA8 LINC01554 LNX2 MAPK6 MIPOL1 OGT PAFAH1B2 POLR1C PTEN RAF1 SH3BP4 SHANK3 SUMO2 UBE2Z VAV2 VHL XRCC6 ZNRD2
Entrez ID		5049	7203
HPRD ID		03940	08969
Ensembl ID		ENSG00000168092	ENSG00000163468
Uniprot IDs		P68402 V9HW44	B3KX11 P49368 Q59H77
PDB IDs		1VYH	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I6J 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		1-alkyl-2-acetylglycerophosphocholine Esterase Complex Positive Regulation Of Monocyte Differentiation Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Diapedesis Reelin-mediated Signaling Pathway Protein Localization To Organelle Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monocyte Differentiation Regulation Of ATP Biosynthetic Process Negative Regulation Of Glycolytic Process Positive Regulation Of Myeloid Cell Differentiation Phospholipase Binding Negative Regulation Of ATP Metabolic Process Response To Glucocorticoid Intracellular Protein Localization Response To Hormone Microtubule Nucleus Regulation Of JNK Cascade Protein-containing Complex Binding Response To Corticosteroid Negative Regulation Of JNK Cascade Positive Regulation Of Cell Growth Positive Regulation Of ATP Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Localization To Mitochondrion Regulation Of Reactive Oxygen Species Biosynthetic Process RNA Binding Cell Population Proliferation Organelle Organization Negative Regulation Of Spontaneous Neurotransmitter Secretion Protein Localization To Nucleus Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Cellular Response To Raffinose Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Erythrocyte Differentiation Response To Steroid Hormone Helper T Cell Diapedesis Leukocyte Migration Positive Regulation Of Protein Localization Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin	Protein Localization To Lysosome Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Protein Localization To Vacuole Postsynaptic Density Assembly ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of TOR Signaling Glial Cell Development Postsynaptic Specialization Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Transcription By RNA Polymerase I Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Cell Size Schwann Cell Development Myelination Axon Ensheathment Cytosol Postsynaptic Density Organization Dendritic Spine Morphogenesis Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription ERBB2 Signaling Pathway Regulation Of Translational Initiation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Postsynaptic Specialization Organization Identical Protein Binding Secretory Granule Lumen Intracellular Signal Transduction Ficolin-1-rich Granule Lumen Nucleus Cytoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Biosynthetic Process Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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