PAFAH1B2 and ACIN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PAFAH1B2	ACIN1
Gene Name		platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	apoptotic chromatin condensation inducer 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity	Nucleotide Binding Nucleic Acid Binding Protein Binding ATPase Activity Enzyme Binding Poly(A) RNA Binding
	Biological Process	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy	MRNA Processing Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis RNA Splicing Erythrocyte Differentiation Apoptotic Chromosome Condensation Positive Regulation Of Apoptotic Process Positive Regulation Of Monocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		14 interactors: ACIN1 ASF1A CCT3 PAFAH1B1 PAFAH1B3 PARK2 PINX1 PPP1R12C REXO1 RPLP0 SLA SNUPN TIMM50 ZFP36L1	11 interactors: ABCF3 AKR1C3 BTBD10 CASP3 CSNK2A1 KLHL26 PAFAH1B2 PCBD1 RNPS1 SRPK2 YWHAG
Entrez ID		5049	22985
HPRD ID		03940	05191
Ensembl ID		ENSG00000168092	ENSG00000100813
Uniprot IDs		P68402	B4DQZ7 Q9UKV3
PDB IDs		1VYH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Organelle Negative Regulation Of JNK Cascade MRNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Cellular Localization RNA Import Into Nucleus Positive Regulation Of Protein Linear Polyubiquitination Proepicardium Development Regulation Of Cytokine-mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Establishment Of Centrosome Localization Adult Locomotory Behavior Catabolic Process Neuromuscular Process Cellular Component Assembly Protein Localization Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Chromosome Condensation Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Platelet Activating Factor Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Single Organism Reproductive Process Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of MAPK Cascade MRNA Catabolic Process Regulation Of JNK Cascade Adult Behavior Positive Regulation Of Monocyte Differentiation	Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Neuron Death Regulation Of Metabolic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Organization Negative Regulation Of Retinoic Acid Biosynthetic Process Catabolic Process Positive Regulation Of Neuron Death Regulation Of MRNA Processing Keratinocyte Differentiation Aromatic Compound Catabolic Process Regulation Of RNA Splicing Regulation Of Testosterone Biosynthetic Process Farnesol Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Isoprenoid Metabolic Process Sesquiterpenoid Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Epidermal Cell Differentiation Cellular Response To Jasmonic Acid Stimulus Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Cellular Response To Prostaglandin D Stimulus Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process System Development Regulation Of Apoptotic DNA Fragmentation Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Testosterone Biosynthetic Process Negative Regulation Of Catalytic Activity Skin Development Negative Regulation Of Cellular Protein Metabolic Process Tetrahydrobiopterin Biosynthetic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation RNA Splicing, Via Transesterification Reactions Regulation Of Neuron Apoptotic Process Lipid Catabolic Process
Tagcloud ?		1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Difference) ?		1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Intersection) ?