GTPBP2 and CLK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GTPBP2	CLK2
Description		GTP binding protein 2	CDC like kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Platelet Alpha Granule Lumen	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Identical Protein Binding Alpha-aminoacyl-tRNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Translational Elongation Nuclear-transcribed MRNA Catabolic Process, No-go Decay Rescue Of Stalled Ribosome	Protein Phosphorylation Response To Ionizing Radiation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways		Platelet degranulation
Drugs			Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: CLK2 GPN3 KDM1A NXF1 PICK1 PLEKHF2 PRMT5 PRMT6 PSMB1 SNRNP70 SUV39H1 TXN2	62 interacting genes: AKT1 AP2M1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUC7L LUZP4 MRPL2 MRPL4 NIP7 NXF1 PATL1 PRM1 PRPF38A PRPF6 PTPN1 RBM39 RBM6 RNF8 RNPS1 RSRP1 SDCBP SNRNP27 SRPK2 SRRM1 SRSF1 SRSF10 SRSF8 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YTHDF1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		54676	1196
HPRD ID		08465	04289
Ensembl ID		ENSG00000172432	ENSG00000176444
Uniprot IDs		A8K2K2 Q9BX10	A8K7I0 B1AVT0 B7Z8N6 P49760
PDB IDs			3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?		Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of MRNA Splicing, Via Spliceosome Histone Methyltransferase Complex Methyltransferase Activity Regulation Of RNA Splicing Chromatin Binding Methylation Positive Regulation Of RNA Splicing Nucleoplasm Cellular Response To Glucose Starvation Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Refolding Chromatin Remodeling P53 Binding Peptidyl-arginine N-methylation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphorylation Negative Regulation Of Metabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Chaperone-mediated Autophagy ENoSc Complex Protein-arginine Omega-N Symmetric Methyltransferase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Nuclear Speck Phosphorylation Macromolecule Metabolic Process Release From Viral Latency Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Secretory Granule Lumen Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Folding Histone H3K9 Trimethyltransferase Activity RDNA Heterochromatin Chromatin Organization Membrane Curvature Sensor Activity Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation	MRNA Metabolic Process MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing, Via Transesterification Reactions RS Domain Binding RNA Processing Nucleus RNA Metabolic Process Nuclear Speck Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleic Acid Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of RNA Metabolic Process Zinc Ion Binding Protein-RNA Complex Assembly Nucleic Acid Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Metabolic Process Spliceosomal Complex Assembly Mammalian Oogenesis Stage Protein Binding MRNA Alternative Polyadenylation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein K6-linked Ubiquitination Protein Serine/threonine/tyrosine Kinase Activity Pre-mRNA 3'-splice Site Binding U2AF Complex MRNA 3'-end Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Translational Initiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response N6-methyladenosine-containing RNA Reader Activity
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