CRLS1 and MCM6

Number of citations of the paper that reports this interaction (PMID 12771218)
15

Data Source:
HPRD (in vivo)

		CRLS1	MCM6
Gene Name		cardiolipin synthase 1	minichromosome maintenance complex component 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Integral Component Of Membrane	Nucleus Nucleoplasm MCM Complex
	Molecular Function	Phosphotransferase Activity, For Other Substituted Phosphate Groups	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Phospholipid Metabolic Process Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways		Acyl chain remodelling of PG Metabolism of lipids and lipoproteins Phospholipid metabolism Glycerophospholipid biosynthesis Synthesis of CL	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: FBXO15 MCM6 MCM7 PINK1	31 interactors: ALS2CR11 CCNA1 CDC45 CDC7 CDKN2A CDT1 CRLS1 DBF4 FAM161A GMNN HDAC1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MLLT3 NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 ZBTB9
Entrez ID		54675	4175
HPRD ID		12187	03485
Ensembl ID		ENSG00000088766	ENSG00000076003
Uniprot IDs		Q9UJA2	Q14566
PDB IDs			2KLQ 2LE8
Enriched GO Terms of Interacting Partners?		DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation DNA Duplex Unwinding DNA Geometric Change DNA-dependent DNA Replication Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Conformation Change Positive Regulation Of Cellular Respiration Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Cellular Response To Hypoxia Positive Regulation Of Dopamine Secretion Peptidyl-serine Autophosphorylation Negative Regulation Of Oxidative Stress-induced Neuron Death TORC2 Signaling Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Mitochondrial Fission Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Oxidative Phosphorylation Regulation Of Mitochondrion Degradation Positive Regulation Of Catecholamine Secretion Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Cellular Respiration Regulation Of Mitochondrial Fission Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Protein Dephosphorylation TOR Signaling Regulation Of Dopamine Secretion Mitotic Cell Cycle Cellular Response To Toxic Substance Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Oxidative Stress-induced Cell Death Response To Epidermal Growth Factor Mitochondrion Degradation	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle DNA Replication Mitotic Cell Cycle Process DNA-dependent DNA Replication DNA Replication Initiation Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication Chromosome Organization Cellular Metabolic Process DNA Conformation Change Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Double-strand Break Repair Cellular Response To Stress Regulation Of Nuclear Cell Cycle DNA Replication DNA Replication Checkpoint Cellular Process Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint DNA Recombination Organelle Organization Negative Regulation Of Cell Cycle
Tagcloud ?			benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Difference) ?			benign bronchial brushing brushings clinicopathologic considerable consisting cytology detecting icbp90 immunocytochemistry inpatients ki67 kiaa0317 kiaa1522 ligase lung mcm7 minichromosome nonsmall nsclc outpatients panel sclc specimens tp53 tp63 uhr1 uncharacterized
Tagcloud (Intersection) ?