CRLS1 and FBXO15

Number of citations of the paper that reports this interaction (PMID 24703837)
2

Data Source:
BioGRID (pull down)

		CRLS1	FBXO15
Gene Name		cardiolipin synthase 1	F-box protein 15
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Integral Component Of Membrane	SCF Ubiquitin Ligase Complex
	Molecular Function	Phosphotransferase Activity, For Other Substituted Phosphate Groups
	Biological Process	Phospholipid Metabolic Process Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways		Acyl chain remodelling of PG Metabolism of lipids and lipoproteins Phospholipid metabolism Glycerophospholipid biosynthesis Synthesis of CL
Drugs
Diseases
GWAS			Sleep duration ( 23728906) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		4 interactors: FBXO15 MCM6 MCM7 PINK1	2 interactors: CRLS1 SKP1
Entrez ID		54675	201456
HPRD ID		12187	16435
Ensembl ID		ENSG00000088766	ENSG00000141665
Uniprot IDs		Q9UJA2	Q8NCQ5
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation DNA Duplex Unwinding DNA Geometric Change DNA-dependent DNA Replication Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Conformation Change Positive Regulation Of Cellular Respiration Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Cellular Response To Hypoxia Positive Regulation Of Dopamine Secretion Peptidyl-serine Autophosphorylation Negative Regulation Of Oxidative Stress-induced Neuron Death TORC2 Signaling Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Mitochondrial Fission Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Oxidative Phosphorylation Regulation Of Mitochondrion Degradation Positive Regulation Of Catecholamine Secretion Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Cellular Respiration Regulation Of Mitochondrial Fission Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Protein Dephosphorylation TOR Signaling Regulation Of Dopamine Secretion Mitotic Cell Cycle Cellular Response To Toxic Substance Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Oxidative Stress-induced Cell Death Response To Epidermal Growth Factor Mitochondrion Degradation	Cardiolipin Biosynthetic Process Histone H2A Monoubiquitination Cardiolipin Metabolic Process Phosphatidylglycerol Biosynthetic Process Histone H2A Ubiquitination Phosphatidylglycerol Acyl-chain Remodeling Histone Monoubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Histone Ubiquitination Protein Monoubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
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