CRLS1 and FBXO15

Number of citations of the paper that reports this interaction (PubMedID 24703837)
64

Data Source:
BioGRID (pull down)

		CRLS1	FBXO15
Description		cardiolipin synthase 1	F-box protein 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Transferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Cardiolipin Synthase (CMP-forming) 2-acylglycerol-3-phosphate O-acyltransferase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Phospholipid Biosynthetic Process Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Glycerophospholipid Biosynthetic Process
Pathways		Acyl chain remodelling of PG Synthesis of CL	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Triglyceride levels x loop diuretics use interaction ( 31806883)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Cervical cancer ( 28806749) Coronary artery calcification ( 23870195) Diastolic blood pressure (alcohol consumption interaction) ( 24376456) Longevity (100 years and older) ( 33948810) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Metabolite levels ( 23823483) Sleep (1/2-day periodicity) ( 33075057) Sleep duration ( 23728906) Smooth-surface caries ( 24556642) Thyroid hormone levels ( 23408906)
Interacting Genes		5 interacting genes: F2RL1 FBXO15 MCM6 MCM7 PINK1	2 interacting genes: CRLS1 SKP1
Entrez ID		54675	201456
HPRD ID		12187	16435
Ensembl ID		ENSG00000088766	ENSG00000141665
Uniprot IDs		Q9UJA2	Q8NCQ5
PDB IDs
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Negative Regulation Of JNK Cascade DNA Helicase Activity Proteinase-activated Receptor Activity Regulation Of JNK Cascade Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Protease Binding Positive Regulation Of Renin Secretion Into Blood Stream Helicase Activity Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Recombinational Repair Regulation Of DNA Replication DNA Replication Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Synaptic Transmission, Dopaminergic Cellular Response To Hydrogen Sulfide Positive Regulation Of Cristae Formation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cristae Formation Negative Regulation Of MAPK Cascade Chromosome, Telomeric Region Positive Regulation Of Killing Of Cells Of Another Organism Response To Hydrogen Sulfide Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity C3HC4-type RING Finger Domain Binding Negative Regulation Of Mitochondrial Fission Maintenance Of Protein Location In Mitochondrion Regulation Of Synaptic Vesicle Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neutrophil Mediated Cytotoxicity Double-strand Break Repair Nuclear DNA Replication	F-box Domain Binding Cul7-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylglycerol Biosynthetic Process Cardiolipin Biosynthetic Process Cardiolipin Synthase (CMP-forming) Ubiquitin Ligase Activator Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Cardiolipin Metabolic Process 1-acylglycerol-3-phosphate O-acyltransferase Activity Maintenance Of Protein Location In Nucleus PcG Protein Complex Cullin Family Protein Binding Molecular Function Activator Activity Positive Regulation Of Epithelial Cell Apoptotic Process Phosphatidylglycerol Metabolic Process Maintenance Of Protein Localization In Organelle Maintenance Of Protein Location Regulation Of Epithelial Cell Apoptotic Process Maintenance Of Protein Location In Cell Protein Monoubiquitination SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Axon Development Maintenance Of Location In Cell Maintenance Of Location Ubiquitin-like Ligase-substrate Adaptor Activity Beta-catenin Binding Protein K48-linked Ubiquitination
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