EGLN1 and EPAS1

Number of citations of the paper that reports this interaction (PMID 15474027)
19

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro)

		EGLN1	EPAS1
Gene Name		egl-9 family hypoxia-inducible factor 1	endothelial PAS domain protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Transcription Factor Complex Cytosol
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Negative Regulation Of CAMP Catabolic Process Oxygen Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Response To Nitric Oxide	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Transcription From RNA Polymerase II Promoter Mitochondrion Organization Signal Transduction Visual Perception Erythrocyte Differentiation Lung Development Somatic Stem Cell Maintenance Norepinephrine Metabolic Process Surfactant Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Myoblast Fate Commitment Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS			Renal cell carcinoma ( 21131975)
Protein-Protein Interactions		10 interactors: EPAS1 FKBP8 HIF1A HIF3A ING4 KRAS OS9 PLD1 SRC ZNF281	32 interactors: APC ARNT ARNT2 ARNTL ARNTL2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 EWSR1 F12 HSP90AA1 JUN KLHL20 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP VHL
Entrez ID		54583	2034
HPRD ID		06971	06787
Ensembl ID		ENSG00000135766	ENSG00000116016
Uniprot IDs		Q9GZT9 R4SCQ0	B3KW07 Q99814
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4KBZ	1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9
Enriched GO Terms of Interacting Partners?		Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Hypoxia Tube Development Response To Stress Cellular Response To Stress Tissue Remodeling Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus Positive Regulation Of Monooxygenase Activity Cellular Response To Stimulus Ras Protein Signal Transduction Regulation Of Gene Expression Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Cell Death Stem Cell Differentiation Signaling Visual Learning Transcription From RNA Polymerase II Promoter Cell Communication Visual Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neural Fold Elevation Formation Regulation Of Transcription, DNA-templated Epithelial Tube Morphogenesis Regulation Of Oxidoreductase Activity Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cell Death Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Associative Learning Regulation Of RNA Metabolic Process Response To Interleukin-1 Response To Oxidative Stress Tube Morphogenesis Epithelium Development Mammary Gland Epithelium Development	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Response To Stimulus Anatomical Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process System Development Developmental Process Nitrogen Compound Metabolic Process RNA Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Cellular Response To Oxygen Levels Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Leukocyte Activation Biosynthetic Process Leukocyte Differentiation Response To External Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Myeloid Leukocyte Differentiation
Tagcloud ?		2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		2alpha adaptation adapted altitude another approaches basis concert egln1 encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide