EGLN1 and ZNF281

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EGLN1	ZNF281
Description		egl-9 family hypoxia inducible factor 1	zinc finger protein 281
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Postsynaptic Density Glutamatergic Synapse	Nucleus Nucleoplasm
	Molecular Function	Enzyme Inhibitor Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia Intracellular Iron Ion Homeostasis Intracellular Oxygen Homeostasis Regulation Of Neuron Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Cellular Response To Hypoxia Response To Nitric Oxide Regulation Of Modification Of Postsynaptic Structure Regulation Protein Catabolic Process At Postsynapse Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Embryonic Body Morphogenesis Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Stem Cell Differentiation
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Ascorbic acid Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE FG-2216 Daprodustat Vadadustat Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Cutaneous mastocytosis ( 32752121) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 27863252 32888494)	Antisaccade task score ( 31596458) Myopia ( 27182965) Neurofibrillary tangles ( 31497858) Prepulse inhibition of the startle response ( 31596458) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: EPAS1 HIF1A HIF3A HSP90AA1 ING4 KRAS OS9 PLD1 SH3KBP1 SRC VHL ZNF281	7 interacting genes: CD247 EGLN1 FBXW11 MYC PIK3R3 STAT3 ZBTB16
Entrez ID		54583	23528
HPRD ID		06971	11702
Ensembl ID		ENSG00000135766	ENSG00000162702
Uniprot IDs		Q9GZT9 R4SCQ0	B3KMX4 Q9Y2X9
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4 6ZBN 6ZBO 7Q5V 7Q5X 7UJV 7UMP 8J1K 8Q5S 8Q64 8Q6D 8Q6E 8RUT 8RUV 8RUZ 8RV1 8Y0V 8Z31 8Z32 8Z33 8Z35
Enriched GO Terms of Interacting Partners?		Intracellular Oxygen Homeostasis Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Hypoxia Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Apoptotic Process TOR Signaling Programmed Cell Death Cell Death Negative Regulation Of TOR Signaling Response To Hypoxia Cellular Response To Stress Response To Decreased Oxygen Levels Positive Regulation Of Multicellular Organismal Process Response To Oxygen Levels Regulation Of Protein Neddylation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Glycolytic Process Epithelial Cell Maturation Embryonic Placenta Development Homeostatic Process Regulation Of TOR Signaling Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Dimerization Activity Regulation Of Gene Expression Hemopoiesis Positive Regulation Of Lamellipodium Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Apoptotic Process Cell Migration Macromolecule Metabolic Process Multicellular Organismal-level Homeostasis Regulation Of Heart Contraction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Neuroblast Proliferation Transcription Regulator Complex Intracellular Chemical Homeostasis Transcription Coactivator Binding Response To Stress Regulation Of Post-translational Protein Modification	Cell Surface Receptor Signaling Pathway T Cell Activation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Oxygen Levels Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Transcription Intracellular Iron Ion Homeostasis Negative Regulation Of Intracellular Signal Transduction Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Protein Dimerization Activity Positive Regulation Of Acinar Cell Proliferation Positive Regulation Of DNA-templated Transcription SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Hypoxia Regulation Of Hemopoiesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of MiRNA Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Alpha-beta T Cell Activation Lymphocyte Activation Negative Regulation Of Myeloid Cell Differentiation Myc-Max Complex Regulation Of Acinar Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Type 2 Angiotensin Receptor Binding Peptidyl-proline Dioxygenase Activity Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Leukocyte Activation Fc-gamma Receptor III Complex Gamma-delta T Cell Receptor Complex NK T Cell Proliferation Regulation Of Cellular Response To Stress Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Male Germ-line Stem Cell Asymmetric Division Regulation Protein Catabolic Process At Postsynapse
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