EGLN1 and ZNF281

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EGLN1	ZNF281
Gene Name		egl-9 family hypoxia-inducible factor 1	zinc finger protein 281
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Negative Regulation Of CAMP Catabolic Process Oxygen Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Response To Nitric Oxide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Embryonic Body Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: EPAS1 FKBP8 HIF1A HIF3A ING4 KRAS OS9 PLD1 SRC ZNF281	4 interactors: CD247 EGLN1 MYC ZBTB16
Entrez ID		54583	23528
HPRD ID		06971	11702
Ensembl ID		ENSG00000135766	ENSG00000162702
Uniprot IDs		Q9GZT9 R4SCQ0	A6NF48 B3KMX4 Q9Y2X9
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4KBZ
Enriched GO Terms of Interacting Partners?		Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Hypoxia Tube Development Response To Stress Cellular Response To Stress Tissue Remodeling Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus Positive Regulation Of Monooxygenase Activity Cellular Response To Stimulus Ras Protein Signal Transduction Regulation Of Gene Expression Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Cell Death Stem Cell Differentiation Signaling Visual Learning Transcription From RNA Polymerase II Promoter Cell Communication Visual Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neural Fold Elevation Formation Regulation Of Transcription, DNA-templated Epithelial Tube Morphogenesis Regulation Of Oxidoreductase Activity Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cell Death Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Associative Learning Regulation Of RNA Metabolic Process Response To Interleukin-1 Response To Oxidative Stress Tube Morphogenesis Epithelium Development Mammary Gland Epithelium Development	Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Mesonephros Development Regulation Of Myeloid Cell Differentiation Fibroblast Apoptotic Process Negative Regulation Of CAMP Catabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Immune System Process Positive Regulation Of NK T Cell Differentiation Regulation Of T Cell Activation Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Cell Activation Kidney Development Negative Regulation Of Monocyte Differentiation Positive Regulation Of Cell Proliferation Involved In Kidney Development Renal System Development Oxygen Homeostasis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Tissue Development Urogenital System Development Regulation Of Lymphocyte Activation Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of Cellular Metabolic Process Response To Nitric Oxide Heart Trabecula Formation Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process 4-hydroxyproline Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Defense Response To Virus By Virus Oxygen Transport Tissue Morphogenesis Peptidyl-proline Hydroxylation Negative Regulation Of Cell Proliferation Heart Trabecula Morphogenesis Protein Hydroxylation Positive Regulation Of Chondrocyte Differentiation
Tagcloud ?		2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	34a accordingly cd133 circuitry crc deregulation ectopic emt feed finger forward kruppel lgr5 microrna mutational nanog oct4 organismal physically pluripotency snail sox2 sphere stemness suppressive tf translated zbp zfp148
Tagcloud (Difference) ?		2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	34a accordingly cd133 circuitry crc deregulation ectopic emt feed finger forward kruppel lgr5 microrna mutational nanog oct4 organismal physically pluripotency snail sox2 sphere stemness suppressive tf translated zbp zfp148
Tagcloud (Intersection) ?