EGLN1 and HIF3A

Number of citations of the paper that reports this interaction (PMID 15474027)
19

Data Source:
HPRD (in vitro)

		EGLN1	HIF3A
Gene Name		egl-9 family hypoxia-inducible factor 1	hypoxia inducible factor 3, alpha subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytosol
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Signal Transducer Activity Protein Dimerization Activity
	Biological Process	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Negative Regulation Of CAMP Catabolic Process Oxygen Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Response To Nitric Oxide	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: EPAS1 FKBP8 HIF1A HIF3A ING4 KRAS OS9 PLD1 SRC ZNF281	6 interactors: EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL
Entrez ID		54583	64344
HPRD ID		06971	17104
Ensembl ID		ENSG00000135766	ENSG00000124440
Uniprot IDs		Q9GZT9 R4SCQ0	B2RBI6 F5H884 H0YDZ5 Q9Y2N7
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4KBZ
Enriched GO Terms of Interacting Partners?		Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Hypoxia Tube Development Response To Stress Cellular Response To Stress Tissue Remodeling Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus Positive Regulation Of Monooxygenase Activity Cellular Response To Stimulus Ras Protein Signal Transduction Regulation Of Gene Expression Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Cell Death Stem Cell Differentiation Signaling Visual Learning Transcription From RNA Polymerase II Promoter Cell Communication Visual Behavior Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neural Fold Elevation Formation Regulation Of Transcription, DNA-templated Epithelial Tube Morphogenesis Regulation Of Oxidoreductase Activity Response To Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cell Death Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Associative Learning Regulation Of RNA Metabolic Process Response To Interleukin-1 Response To Oxidative Stress Tube Morphogenesis Epithelium Development Mammary Gland Epithelium Development	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Peptidyl-proline Hydroxylation Response To Abiotic Stimulus 4-hydroxyproline Metabolic Process Protein Hydroxylation Cellular Response To Stress Oxygen Homeostasis Monocarboxylic Acid Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neuron Apoptotic Process Cellular Modified Amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Regulation Of Neuron Death Regulation Of Nitric-oxide Synthase Activity Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Amino Acid Metabolic Process Regulation Of Oxidoreductase Activity Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Neural Fold Elevation Formation Cardiac Ventricle Development Positive Regulation Of Metabolic Process Embryonic Placenta Development Cellular Response To Stimulus Elastin Metabolic Process Negative Regulation Of CAMP Catabolic Process Cardiac Chamber Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Intestinal Epithelial Cell Maturation Placenta Development Regulation Of Transcription, DNA-templated
Tagcloud ?		2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxia hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg
Tagcloud (Difference) ?		2alpha adaptation adapted altitude another approaches basis concert encodes epas1 hif hif2a humans hydroxylase inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg
Tagcloud (Intersection) ?		hypoxia