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EGLN1
Gene Name
egl-9 family hypoxia-inducible factor 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Molecular Function
Iron Ion Binding
Protein Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
Enzyme Binding
L-ascorbic Acid Binding
Peptidyl-proline Dioxygenase Activity
Peptidyl-proline 4-dioxygenase Activity
Biological Process
Response To Hypoxia
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Negative Regulation Of CAMP Catabolic Process
Oxygen Homeostasis
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Angiogenesis
Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Cardiac Muscle Tissue Morphogenesis
Oxidation-reduction Process
Heart Trabecula Formation
Ventricular Septum Morphogenesis
Labyrinthine Layer Development
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Response To Nitric Oxide
Pathways
Cellular response to hypoxia
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Protein-protein Interactions
10 interactors:
EPAS1
FKBP8
HIF1A
HIF3A
ING4
KRAS
OS9
PLD1
SRC
ZNF281
Entrez ID
54583
HPRD ID
06971
Ensembl ID
ENSG00000135766
Uniprot IDs
Q9GZT9
R4SCQ0
PDB IDs
2G19
2G1M
2HBT
2HBU
2Y33
2Y34
3HQR
3HQU
3OUH
3OUI
3OUJ
4BQW
4BQX
4BQY
4KBZ
Enriched GO Terms of Interacting Partners
?
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Oxygen Levels
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Response To Hypoxia
Tube Development
Response To Stress
Cellular Response To Stress
Tissue Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Positive Regulation Of Nitric-oxide Synthase Activity
Response To Abiotic Stimulus
Positive Regulation Of Monooxygenase Activity
Cellular Response To Stimulus
Ras Protein Signal Transduction
Regulation Of Gene Expression
Regulation Of Nitric-oxide Synthase Activity
Response To Mineralocorticoid
Positive Regulation Of Oxidoreductase Activity
Signal Transduction
Regulation Of Apoptotic Process
Positive Regulation Of Gene Expression
Cellular Metabolic Process
Regulation Of Cell Death
Stem Cell Differentiation
Signaling
Visual Learning
Transcription From RNA Polymerase II Promoter
Cell Communication
Visual Behavior
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Neural Fold Elevation Formation
Regulation Of Transcription, DNA-templated
Epithelial Tube Morphogenesis
Regulation Of Oxidoreductase Activity
Response To Stimulus
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Cell Death
Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Associative Learning
Regulation Of RNA Metabolic Process
Response To Interleukin-1
Response To Oxidative Stress
Tube Morphogenesis
Epithelium Development
Mammary Gland Epithelium Development
Tagcloud
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2alpha
adaptation
adapted
altitude
another
approaches
basis
concert
encodes
epas1
hif
hif2a
humans
hydroxylase
hypoxia
inducible
locations
offer
orchestrates
phd2
populations
prolyl
regulators
signatures
tibetans
toward
treating
unraveling
wide