IL1R1 and IL1RAP

Number of citations: 24 (PubMedID 9371760)
Data Source: HPRD (in vitro, in vivo)

		IL1R1	IL1RAP
Name		interleukin 1 receptor type 1	interleukin 1 receptor accessory protein
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Plasma Membrane Cell Surface Membrane Synapse Glutamatergic Synapse
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Coreceptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway	Immune System Process Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS	None
Drugs		Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)	None
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Alanine aminotransferase levels ( 33547301 ) Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Ankylosing spondylitis ( 23749187 ) Asthma ( 31959851 31619474 29785011 30929738 22561531 ) Asthma (childhood onset) ( 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Blood protein levels ( 30072576 ) C-reactive protein levels ( 30388399 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Inflammatory bowel disease ( 28067908 23128233 ) Primary biliary cholangitis ( 26394269 ) Serum protein levels (sST2) ( 23999434 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )	Blood protein levels ( 30072576 ) Longitudinal change in brain amyloid plaque burden ( 26268530 ) Lung cancer ( 18385676 ) Waist circumference ( 20966902 )
Novel Interactors		1 novel interactors: HYOU1	2 novel interactors: AP2M1 FXR1
Interacting Genes		11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		3554	3556
HPRD ID		00994	04021
Ensembl ID		ENSG00000115594	ENSG00000196083
Uniprot IDs		B8ZZW4 P14778	A8K6K4 Q9NPH3
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF	3O4O 4DEP 7FCC
GO Terms Enriched among Interactors		Interleukin-1 Receptor Binding Inflammatory Response Interleukin-1-mediated Signaling Pathway Defense Response Cytokine-mediated Signaling Pathway Response To Stress Immune Response Acute-phase Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Acute Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-6 Production Interleukin-1, Type I Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Response To Lipopolysaccharide Fever Generation Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Bacterial Origin Signal Transduction Regulation Of Interleukin-6 Production Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immature T Cell Proliferation In Thymus Molecular Adaptor Activity Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Binding Response To Lipid Heat Generation Cellular Response To Lipid Toll Signaling Pathway Cytokine Activity Cellular Response To Oxygen-containing Compound Interleukin-33-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway Negative Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Extrinsic Component Of Plasma Membrane Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity	Regulation Of Cytokine Production Cytokine-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Multicellular Organismal Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response Positive Regulation Of Cytokine Production Inflammatory Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Interleukin-1 Receptor Activity Immune System Process Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Interleukin-1 Receptor Binding Regulation Of Defense Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of T-helper 1 Type Immune Response Response To Lipopolysaccharide Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Cytokine Production Involved In Inflammatory Response Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Glutamatergic Synapse Positive Regulation Of Cytokine Production Involved In Immune Response Response To Peptide Fever Generation Positive Regulation Of Transport Positive Regulation Of Interleukin-6 Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of Multicellular Organismal Process