IL1R1 and IL1RAP

Number of citations of the paper that reports this interaction (PMID 9371760)
28

Data Source:
HPRD (in vivo, in vitro)

		IL1R1	IL1RAP
Gene Name		interleukin 1 receptor, type I	interleukin 1 receptor accessory protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Protease Binding Signal Transducer Activity Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding	Signal Transducer Activity Interleukin-1 Receptor Activity
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Protein Complex Assembly Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs		Anakinra
Diseases
GWAS		Asthma ( 22561531) Inflammatory bowel disease ( 23128233)	Lung cancer ( 18385676) Waist circumference ( 20966902)
Protein-Protein Interactions		11 interactors: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	19 interactors: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCH8 MC4R MYD88 PIK3R1 PRKCI PRPF40A RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		3554	3556
HPRD ID		00994	04021
Ensembl ID		ENSG00000115594	ENSG00000196083
Uniprot IDs		P14778	A8K6K4 Q9NPH3
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF	3O4O 4DEP
Enriched GO Terms of Interacting Partners?		Inflammatory Response Defense Response Response To Cytokine Immune Response Fever Generation Heat Generation Acute-phase Response Cellular Response To Organic Substance Regulation Of Chemokine Production Cytokine-mediated Signaling Pathway Immune System Process Acute Inflammatory Response Response To Stress Regulation Of Cytokine Production Response To Organic Substance Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Cytokine Biosynthetic Process Signaling Response To Lipopolysaccharide Temperature Homeostasis Cell Communication Positive Regulation Of JNK Cascade Response To Molecule Of Bacterial Origin Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Cellular Response To Lipopolysaccharide Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Regulation Of JNK Cascade Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Cellular Response To Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Stress-activated MAPK Cascade Response To Bacterium Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Chemokine Biosynthetic Process See more	Response To Cytokine Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Immune System Process Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cytokine Production Defense Response Response To Interleukin-1 Signaling Cell Communication Temperature Homeostasis Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of NF-kappaB Transcription Factor Activity Fever Generation Acute-phase Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Intracellular Signal Transduction Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Protein Transport Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Positive Regulation Of Immune Response Positive Regulation Of Intracellular Protein Transport Cellular Response To Molecule Of Bacterial Origin Regulation Of Protein Import Into Nucleus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Regulation Of Chemokine Production Heat Generation Response To Stimulus See more
Tagcloud ?		a2 cdk2 cyclin depleting depletion diminish dst emerging endogenous extra fkbp5 hef1 investigates isoform measuring p21 p27 pr predominantly progesterone progestin q regulating repressed repression sgk1 t47d target tethering	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Difference) ?		a2 cdk2 cyclin depleting depletion diminish dst emerging endogenous extra fkbp5 hef1 investigates isoform measuring p21 p27 pr predominantly progesterone progestin q regulating repressed repression sgk1 t47d target tethering	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Intersection) ?