IL1R1 and IL1RN

Number of citations of the paper that reports this interaction (PMID 9062194)
23

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro, in vivo)

		IL1R1	IL1RN
Gene Name		interleukin 1 receptor, type I	interleukin 1 receptor antagonist
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane	Extracellular Space Intracellular Cytoplasm Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Signal Transducer Activity Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Fever Generation Negative Regulation Of Cytokine-mediated Signaling Pathway Chronic Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Acute-phase Response Immune Response Female Pregnancy Memory Negative Regulation Of Glutamate Secretion Response To Activity Sensory Perception Of Pain Carboxylic Acid Metabolic Process Insulin Secretion Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Drug Response To Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Negative Regulation Of Membrane Potential Response To Glucocorticoid Response To Interleukin-1 Response To Interleukin-4 Cellular Response To Norepinephrine Stimulus Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs		Anakinra
Diseases
GWAS		Asthma ( 22561531) Inflammatory bowel disease ( 23128233)	C-reactive protein ( 22939635) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		11 interactors: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	4 interactors: IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		3554	3557
HPRD ID		00994	00978
Ensembl ID		ENSG00000115594	ENSG00000136689
Uniprot IDs		P14778	P18510
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?		Inflammatory Response Defense Response Response To Cytokine Immune Response Fever Generation Heat Generation Acute-phase Response Cellular Response To Organic Substance Regulation Of Chemokine Production Cytokine-mediated Signaling Pathway Immune System Process Acute Inflammatory Response Response To Stress Regulation Of Cytokine Production Response To Organic Substance Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Cytokine Biosynthetic Process Signaling Response To Lipopolysaccharide Temperature Homeostasis Cell Communication Positive Regulation Of JNK Cascade Response To Molecule Of Bacterial Origin Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cytokine Production Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Cellular Response To Lipopolysaccharide Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Molecule Of Bacterial Origin Regulation Of JNK Cascade Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Cellular Response To Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Stress-activated MAPK Cascade Response To Bacterium Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Chemokine Biosynthetic Process	Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of Chromosome Organization Telomere Formation Via Telomerase Protection From Non-homologous End Joining At Telomere DNA Replication Positive Regulation Of Helicase Activity Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Interleukin-1-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Cytokine-mediated Signaling Pathway Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomerase Activity Positive Regulation Of DNA Biosynthetic Process Cellular Response To Cytokine Stimulus Negative Regulation Of DNA Recombination Negative Regulation Of DNA Biosynthetic Process Regulation Of Double-strand Break Repair Protein Localization To Chromosome Response To Cytokine Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Response To Interleukin-1 Regulation Of Organelle Organization Chromosome Organization Regulation Of DNA Repair DNA Metabolic Process Positive Regulation Of DNA Replication Regulation Of DNA Recombination DNA Duplex Unwinding Response To Interleukin-1 DNA Geometric Change Immune Response Homeostatic Process
Tagcloud ?		a2 cdk2 cyclin depleting depletion diminish dst emerging endogenous extra fkbp5 hef1 investigates isoform measuring p21 p27 pr predominantly progesterone progestin q regulating repressed repression sgk1 t47d target tethering	asp299gly constant cosegregating differentially dysregulation endorsed explored fatigue genotyped investigating ischemic link nucleotide opposing polymorphisms poststroke psf remarkably rs4251961 rs4986790 rs4986791 snp snps stroke substitution substudy thr399ile tlr4 toll
Tagcloud (Difference) ?		a2 cdk2 cyclin depleting depletion diminish dst emerging endogenous extra fkbp5 hef1 investigates isoform measuring p21 p27 pr predominantly progesterone progestin q regulating repressed repression sgk1 t47d target tethering	asp299gly constant cosegregating differentially dysregulation endorsed explored fatigue genotyped investigating ischemic link nucleotide opposing polymorphisms poststroke psf remarkably rs4251961 rs4986790 rs4986791 snp snps stroke substitution substudy thr399ile tlr4 toll
Tagcloud (Intersection) ?