IL1R1 and IL1A

Number of citations: 0 (PubMedID 2946959)
Data Source: HPRD (in vitro, in vivo)

		IL1R1	IL1A
Name		interleukin 1 receptor type 1	interleukin 1 alpha
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Intracellular Sodium Ion Homeostasis Apoptotic Process Response To Stress Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cell Division Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS	Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs		Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)	Rilonacept
Diseases		None	Graft-versus-host disease
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Alanine aminotransferase levels ( 33547301 ) Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Ankylosing spondylitis ( 23749187 ) Asthma ( 31959851 31619474 29785011 30929738 22561531 ) Asthma (childhood onset) ( 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Blood protein levels ( 30072576 ) C-reactive protein levels ( 30388399 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Inflammatory bowel disease ( 28067908 23128233 ) Primary biliary cholangitis ( 26394269 ) Serum protein levels (sST2) ( 23999434 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )	Dysmenorrheic pain severity ( 29855537 ) Endometriosis ( 20844546 28537267 ) Gestational age at birth (child effect) ( 31477735 ) Interleukin-1-receptor antagonist levels ( 22205395 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Post-term birth ( 31477735 ) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309 )
Interacting Genes		11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		3554	3552
HPRD ID		00994	00988
Ensembl ID		ENSG00000115594	ENSG00000115008
Uniprot IDs		B8ZZW4 P14778	P01583
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF	2ILA 2KKI 2L5X 5UC6
GO Terms Enriched among Interactors		Interleukin-1 Receptor Binding Inflammatory Response Interleukin-1-mediated Signaling Pathway Defense Response Cytokine-mediated Signaling Pathway Response To Stress Immune Response Acute-phase Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Acute Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-6 Production Interleukin-1, Type I Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Response To Lipopolysaccharide Fever Generation Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Bacterial Origin Signal Transduction Regulation Of Interleukin-6 Production Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immature T Cell Proliferation In Thymus Molecular Adaptor Activity Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Binding Response To Lipid Heat Generation Cellular Response To Lipid Toll Signaling Pathway Cytokine Activity Cellular Response To Oxygen-containing Compound Interleukin-33-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway Negative Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Extrinsic Component Of Plasma Membrane Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity	Interleukin-1 Binding Interleukin-1 Receptor Activity Interleukin-1-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Response To Cytokine Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Interleukin-1, Type I, Activating Receptor Activity Interleukin-33 Receptor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Alpha Production Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin AIM2 Inflammasome Complex IPAF Inflammasome Complex Calpain Complex Viral Penetration Into Host Nucleus Mammary Gland Involution Cysteine-type Peptidase Activity Cytokine Precursor Processing Positive Regulation Of Neutrophil Extravasation Somite Specification Granulocyte Colony-stimulating Factor Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Peptide