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IL1R1 and IL1F10
Number of citations of the paper that reports this interaction (PubMedID
11278614
)
0
Data Source:
HPRD
(in vitro)
IL1R1
IL1F10
Description
interleukin 1 receptor type 1
interleukin 1 family member 10
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Molecular Function
Protease Binding
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Interleukin-1 Receptor Activity
Interleukin-1, Type I, Activating Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Hydrolase Activity
Interleukin-1 Binding
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Cytokine Activity
Interleukin-1 Receptor Binding
Protein Binding
Biological Process
Inflammatory Response
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Smooth Muscle Adaptation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Inflammatory Response
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of T-helper 1 Cell Cytokine Production
Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Inflammatory Response
Immune Response
Cytokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Pathways
Interleukin-10 signaling
Interleukin-1 signaling
Potential therapeutics for SARS
Interleukin-38 signaling
Interleukin-36 pathway
Drugs
Anakinra
SD118
OMS-103HP
Foreskin fibroblast (neonatal)
Diseases
GWAS
Acute anterior uveitis (with or without ankylosing spondylitis) (
25200001
)
Alanine aminotransferase levels (
33547301
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Ankylosing spondylitis (
23749187
)
Asthma (
31959851
31619474
29785011
30929738
22561531
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Blood protein levels (
30072576
)
C-reactive protein levels (
30388399
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Inflammatory bowel disease (
28067908
23128233
)
Primary biliary cholangitis (
26394269
)
Serum protein levels (sST2) (
23999434
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Alanine aminotransferase levels (
34315874
)
Aspartate aminotransferase levels (
34315874
33547301
)
C-reactive protein (
22939635
)
C-reactive protein levels (
33339817
21300955
30388399
)
C-reactive protein levels or LDL-cholesterol levels (pleiotropy) (
27286809
)
C-reactive protein levels or total cholesterol levels (pleiotropy) (
27286809
)
C-reactive protein levels or triglyceride levels (pleiotropy) (
27286809
)
Coronary artery disease (
29212778
)
Dysmenorrheic pain (
27454463
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Inflammatory biomarkers (
24182552
)
Interleukin-1-receptor antagonist levels (
22205395
)
Interleukin-6 levels (
33517400
)
Low density lipoprotein cholesterol levels (
32154731
)
Myocardial infarction (
33532862
)
Serum alkaline phosphatase levels (
33547301
)
Stroke (
26089329
)
Total cholesterol levels (
29083408
)
Interacting Genes
11 interacting genes:
IL1A
IL1B
IL1F10
IL1RAP
IL1RN
IRAK2
MYD88
PIK3R1
SIGIRR
TICAM2
TOLLIP
2 interacting genes:
IL1R1
IMPDH2
Entrez ID
3554
84639
HPRD ID
00994
17144
Ensembl ID
ENSG00000115594
ENSG00000136697
Uniprot IDs
B8ZZW4
P14778
Q8WWZ1
PDB IDs
1G0Y
1IRA
1ITB
4DEP
4GAF
5BOW
Enriched GO Terms of Interacting Partners
?
Interleukin-1 Receptor Binding
Inflammatory Response
Interleukin-1-mediated Signaling Pathway
Defense Response
Cytokine-mediated Signaling Pathway
Response To Stress
Immune Response
Acute-phase Response
Immune System Process
Cell Surface Receptor Signaling Pathway
Cellular Response To Lipopolysaccharide
Acute Inflammatory Response
Cellular Response To Molecule Of Bacterial Origin
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Response To External Biotic Stimulus
Positive Regulation Of Interleukin-6 Production
Interleukin-1, Type I Receptor Binding
Positive Regulation Of Cytokine Production
Regulation Of Chemokine Production
Response To Lipopolysaccharide
Fever Generation
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Toll-like Receptor 4 Signaling Pathway
Response To Molecule Of Bacterial Origin
Signal Transduction
Regulation Of Interleukin-6 Production
Toll-like Receptor 4 Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Immature T Cell Proliferation In Thymus
Molecular Adaptor Activity
Cell Surface Pattern Recognition Receptor Signaling Pathway
Toll-like Receptor Binding
Response To Lipid
Heat Generation
Cellular Response To Lipid
Toll Signaling Pathway
Cytokine Activity
Cellular Response To Oxygen-containing Compound
Interleukin-33-mediated Signaling Pathway
Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Chemokine Production
Extrinsic Component Of Plasma Membrane
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Signaling Adaptor Activity
Interleukin-1 Binding
Smooth Muscle Adaptation
Response To Peptide
Positive Regulation Of Neutrophil Extravasation
Regulation Of Neutrophil Extravasation
Interleukin-1, Type I, Activating Receptor Activity
Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Response To Cytokine
Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Interleukin-1 Receptor Activity
Positive Regulation Of T-helper 1 Cell Cytokine Production
GTP Biosynthetic Process
'de Novo' XMP Biosynthetic Process
IMP Dehydrogenase Activity
Regulation Of Interleukin-1-mediated Signaling Pathway
Platelet-derived Growth Factor Receptor Binding
GMP Biosynthetic Process
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Positive Regulation Of Cellular Extravasation
Positive Regulation Of T-helper 1 Type Immune Response
Purine Ribonucleoside Monophosphate Biosynthetic Process
GTP Metabolic Process
Cellular Response To Interleukin-4
Interleukin-1-mediated Signaling Pathway
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Response To Interleukin-4
GMP Metabolic Process
Positive Regulation Of T Cell Cytokine Production
Positive Regulation Of Neutrophil Migration
Ribonucleoside Monophosphate Biosynthetic Process
Regulation Of Cellular Extravasation
Regulation Of T Cell Cytokine Production
Regulation Of Neutrophil Migration
Nucleoside Monophosphate Biosynthetic Process
Cytokine Receptor Activity
Positive Regulation Of Cytokine-mediated Signaling Pathway
Peroxisomal Membrane
Positive Regulation Of Response To Cytokine Stimulus
Positive Regulation Of Type II Interferon Production
Positive Regulation Of T Cell Mediated Immunity
Nucleoside Monophosphate Metabolic Process
Response To Interleukin-1
Positive Regulation Of Cytokine Production Involved In Immune Response
Immune System Process
Nucleoside Triphosphate Biosynthetic Process
Regulation Of T Cell Mediated Immunity
Protease Binding
Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Regulation Of Type II Interferon Production
Extracellular Region
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Tagcloud (Intersection)
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