RAB5C and TBC1D15

Number of citations of the paper that reports this interaction (PubMedID 16923123)
0

Data Source:
BioGRID (two hybrid)

		RAB5C	TBC1D15
Description		RAB5C, member RAS oncogene family	TBC1 domain family member 15
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome	Extracellular Region Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding	GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Regulation Of Endocytosis Plasma Membrane To Endosome Transport	Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry	TBC/RABGAPs
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fibrinogen levels ( 26561523 28107422) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)	Inferior parietal cortex volume ( 31530798) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: ALS2CL APP APPL2 EEA1 ERBB2 GLP1R HRAS INCA1 RABAC1 RBSN RIN2 RIN3 SGSM3 SNCA SREK1 TBC1D15 TBC1D17	9 interacting genes: CALCOCO1 CEP63 FIS1 OPTN RAB5A RAB5B RAB5C TAX1BP1 UBC
Entrez ID		5878	64786
HPRD ID		04947	15470
Ensembl ID		ENSG00000108774	ENSG00000121749
Uniprot IDs		P51148	A8K8E1 Q8TC07
PDB IDs		4KYI
Enriched GO Terms of Interacting Partners?		Cytoplasmic Vesicle Vesicle-mediated Transport GTPase Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Import Into Cell Endocytosis Endosomal Transport Small GTPase Binding Endosome Regulation Of Endocytosis Regulation Of Neuronal Synaptic Plasticity Early Endosome Intracellular Transport Intracellular Signaling Cassette Cellular Localization Glial Cell Development Establishment Of Localization In Cell Early Endosome Membrane Guanyl-nucleotide Exchange Factor Activity Presynapse Protein Tetramerization Regulation Of Cell Projection Assembly Schwann Cell Development Regulation Of Cilium Assembly Regulation Of Neurotransmitter Uptake Small GTPase-mediated Signal Transduction Cellular Response To Copper Ion Cellular Response To Growth Factor Stimulus Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Protein Targeting To Membrane Amyloid Fibril Formation Regulation Of Vesicle-mediated Transport Regulation Of Cellular Component Organization Microglial Cell Activation Regulation Of Catalytic Activity Response To Growth Factor Recycling Endosome Regulation Of Protein Targeting To Membrane Leukocyte Activation Involved In Inflammatory Response Response To Copper Ion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endocytosis Signal Transduction Glucagon-like Peptide 1 Receptor Activity Response To Desipramine	Plasma Membrane To Endosome Transport GDP Binding Endocytic Vesicle G Protein Activity Melanosome Early Endosome Membrane Establishment Of Protein Localization Endomembrane System Endosomal Transport Endosome Early Endosome GTPase Activity GTP Binding Endosome Organization Autophagosome Intracellular Protein Localization Protein Localization To Phagocytic Vesicle Negative Regulation Of Canonical NF-kappaB Signal Transduction Endocytosis Protein Transport Protein Localization To Early Endosome Response To Flavonoid Cytoplasmic Side Of Early Endosome Membrane Vesicle-mediated Transport Extracellular Exosome Synaptic Vesicle Membrane Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Negative Regulation Of Receptor Recycling Type 2 Mitophagy Response To Fluoride Response To Hypobaric Hypoxia Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Protein Localization To Organelle Import Into Cell Amyloid-beta Clearance By Transcytosis Innate Immune Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Xenophagy Molecular Adaptor Activity Negative Regulation Of Fatty Acid Transport Cellular Response To Peptide Negative Regulation Of Protein Polyubiquitination Regulation Of Endosome Size Cytosol Cellular Localization Organelle Organization Mitochondrial Outer Membrane
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