RAB5C and RIN3

Number of citations of the paper that reports this interaction (PMID 12972505)
26

Data Source:
HPRD (two hybrid)

		RAB5C	RIN3
Gene Name		RAB5C, member RAS oncogene family	Ras and Rab interactor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Early Endosome Lipid Particle Plasma Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Early Endosome Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Intracellular Protein Transport Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport	Endocytosis Signal Transduction Positive Regulation Of Rab GTPase Activity
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767) Paget's disease ( 21623375)
Protein-Protein Interactions		10 interactors: APP APPL2 EEA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17	7 interactors: BIN1 RAB5A RAB5B RAB5C RABAC1 RGS2 TNFAIP1
Entrez ID		5878	79890
HPRD ID		04947	11494
Ensembl ID		ENSG00000108774	ENSG00000100599
Uniprot IDs		P51148	Q86U22 Q8TB24
PDB IDs			3U23
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Ras GTPase Activity Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of GTPase Activity Regulation Of Signal Transduction Regulation Of Signaling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Endosomal Transport Endocytosis Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Regulation Of Intracellular Signal Transduction Mating Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Regulation Of ERBB Signaling Pathway Synaptic Vesicle To Endosome Fusion Feeding Behavior Cholesterol Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Receptor Activity Sterol Metabolic Process Neuromuscular Process Intracellular Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Binding Transition Metal Ion Homeostasis Transport Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Peptidyl-tyrosine Phosphorylation Axon Choice Point Recognition Plasma Membrane To Endosome Transport Locomotory Behavior Establishment Of Localization In Cell	Regulation Of Endocytosis Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport Plasma Membrane To Endosome Transport Endosomal Transport Ras Protein Signal Transduction Regulation Of Cellular Component Organization Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Cytoplasmic Transport Lipid Tube Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Intracellular Protein Transport Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Positive Regulation Of Astrocyte Differentiation Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Cellular Protein Localization Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Stress Fiber Assembly Protein Transport Negative Regulation Of Smooth Muscle Contraction Establishment Of Protein Localization Negative Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Intracellular Transport Negative Regulation Of Lipase Activity Early Endosome To Late Endosome Transport Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Astrocyte Differentiation Endosome Organization Regulation Of Cardiac Muscle Hypertrophy Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signal Transduction Regulation Of Synaptic Vesicle Exocytosis Vasodilation
Tagcloud ?		cdc42 compartment coordinately cytomegalovirus ectopic encode golgi hcmv herpesviruses infectious micrornas mirna mirnas mirs morphogenesis noninfectious rab11a reorganization resemble secretory sirnas snap23 stacks ul112 uncovered us5 vac vamp3 virion	abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Difference) ?		cdc42 compartment coordinately cytomegalovirus ectopic encode golgi hcmv herpesviruses infectious micrornas mirna mirnas mirs morphogenesis noninfectious rab11a reorganization resemble secretory sirnas snap23 stacks ul112 uncovered us5 vac vamp3 virion	abca7 bin1 cass4 cd2ap cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Intersection) ?