GNG2 and ADRA2A

Number of citations of the paper that reports this interaction (PMID 15782186)
67

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GNG2	ADRA2A
Gene Name		guanine nucleotide binding protein (G protein), gamma 2	adrenoceptor alpha 2A
Image
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex Synapse
	Molecular Function	Signal Transducer Activity G-protein Beta-subunit Binding	Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding
	Biological Process	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	Positive Regulation Of Cytokine Production Acute Inflammatory Response Energy Reserve Metabolic Process DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Ras Protein Signal Transduction Rho Protein Signal Transduction Female Pregnancy Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Negative Regulation Of CAMP Biosynthetic Process Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Glucose Homeostasis Fear Response Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Vasodilation Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Thermoception Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Uterine Smooth Muscle Contraction Negative Regulation Of Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Integration of energy metabolism Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Regulation of insulin secretion Amine ligand-binding receptors Platelet Aggregation (Plug Formation) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Adrenaline,noradrenaline inhibits insulin secretion GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Halothane	Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Pramipexole Dipivefrin Brimonidine Amoxapine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Risperidone Epinastine Tolazoline Fenoldopam Pseudoephedrine Benzphetamine Phenoxybenzamine Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Doxepin Nefazodone Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Dihydroergotoxine Ephedra Yohimbine Methotrimeprazine 4-Methoxyamphetamine Methamphetamine Propericiazine Zuclopenthixol Dronedarone Lofexidine Mianserin Asenapine Droxidopa Xylometazoline Naphazoline Lurasidone
Diseases
GWAS		Non-melanoma skin cancer ( 23548203)	Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Platelet aggregation ( 20526338)
Protein-Protein Interactions		15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R	13 interactors: ADRB1 ADRBK1 EIF2B1 GNAI1 GNAI2 GNAO1 GNB1 GNG2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ
Entrez ID		54331	150
HPRD ID		16234	00078
Ensembl ID		ENSG00000186469	ENSG00000150594
Uniprot IDs		P59768	P08913
PDB IDs		4KFM	1HLL 1HO9 1HOD 1HOF
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Stress Blood Coagulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Hemostasis Cell Activation Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Heart Contraction Response To Organonitrogen Compound Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Cell Communication Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Synaptic Transmission Response To Organic Substance Regulation Of Ion Transport Regulation Of Striated Muscle Contraction Cellular Response To Prostaglandin E Stimulus Response To Stimulus Regulation Of Signal Transduction Cell Proliferation Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Energy Reserve Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Signaling Regulation Of Muscle Contraction Positive Regulation Of Catalytic Activity Response To Peptide Hormone Cellular Response To Catecholamine Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Peptide Regulation Of The Force Of Heart Contraction Regulation Of Cellular Process Regulation Of Calcium Ion Transport Positive Regulation Of Hydrolase Activity Response To Morphine Cellular Response To Glucagon Stimulus
Tagcloud ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill
Tagcloud (Difference) ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill
Tagcloud (Intersection) ?