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GNG2 and PGGT1B
Number of citations of the paper that reports this interaction (PMID
15451670
)
58
Data Source:
HPRD
(in vitro)
GNG2
PGGT1B
Gene Name
guanine nucleotide binding protein (G protein), gamma 2
protein geranylgeranyltransferase type I, beta subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Extracellular Vesicular Exosome
CAAX-protein Geranylgeranyltransferase Complex
Molecular Function
Signal Transducer Activity
G-protein Beta-subunit Binding
Protein Geranylgeranyltransferase Activity
CAAX-protein Geranylgeranyltransferase Activity
Drug Binding
Zinc Ion Binding
Isoprenoid Binding
Peptide Binding
Biological Process
Energy Reserve Metabolic Process
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Synaptic Transmission
Blood Coagulation
Cell Proliferation
Platelet Activation
Small Molecule Metabolic Process
Cellular Response To Glucagon Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Catecholamine Stimulus
Positive Regulation Of Cell Proliferation
Protein Geranylgeranylation
Response To Cytokine
Positive Regulation Of Cell Cycle
Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
G alpha (s) signalling events
Activation of GABAB receptors
Glucagon-type ligand receptors
G beta:gamma signalling through PLC beta
Signaling by Wnt
Metabolic disorders of biological oxidation enzymes
G protein gated Potassium channels
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ADP signalling through P2Y purinoceptor 12
Glucagon signaling in metabolic regulation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Inwardly rectifying K+ channels
G-protein beta:gamma signalling
Opioid Signalling
Activation of Kainate Receptors upon glutamate binding
Aquaporin-mediated transport
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (q) signalling events
GPCR downstream signaling
Platelet homeostasis
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
G alpha (q) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signal amplification
Potassium Channels
G beta:gamma signalling through PI3Kgamma
G alpha (12/13) signalling events
Class B/2 (Secretin family receptors)
Prostacyclin signalling through prostacyclin receptor
GABA B receptor activation
GABA receptor activation
Activation of G protein gated Potassium channels
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
GPCR ligand binding
beta-catenin independent WNT signaling
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Ca2+ pathway
G-protein activation
Drugs
Halothane
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
GERANYLGERANYL DIPHOSPHATE
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS
Non-melanoma skin cancer (
23548203
)
Protein-Protein Interactions
15 interactors:
ADRA2A
ADRB2
AVPR2
BTK
CACNA1H
CHRM2
GNB1
GNB3
GNB4
GNB5
MRGPRX1
PGGT1B
PLEKHG2
SMURF2
TBXA2R
5 interactors:
CDC42
GNG2
KRAS
RHOB
RRAS2
Entrez ID
54331
5229
HPRD ID
16234
03612
Ensembl ID
ENSG00000186469
ENSG00000164219
Uniprot IDs
P59768
P53609
PDB IDs
4KFM
Enriched GO Terms of Interacting Partners
?
G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Response To Organic Substance
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Response To Stimulus
Cellular Response To Stimulus
Signal Transduction
Signaling
Cell Communication
Cellular Response To Hormone Stimulus
Energy Reserve Metabolic Process
Cellular Response To Glucagon Stimulus
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Blood Pressure
Regulation Of Smooth Muscle Contraction
Response To Glucagon
Cellular Response To Organic Substance
Regulation Of Adenylate Cyclase Activity
Regulation Of Vasoconstriction
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Regulation Of Cyclase Activity
Response To Hormone
Regulation Of CAMP Biosynthetic Process
Energy Derivation By Oxidation Of Organic Compounds
Regulation Of CAMP Metabolic Process
Regulation Of Cellular Process
Blood Circulation
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Negative Regulation Of Smooth Muscle Contraction
Adrenergic Receptor Signaling Pathway
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Response To External Stimulus
Negative Regulation Of Muscle Contraction
Generation Of Precursor Metabolites And Energy
Homeostatic Process
Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration
Hemostasis
Regulation Of Rhodopsin Mediated Signaling Pathway
Regulation Of Muscle Contraction
Chemical Homeostasis
Activation Of Adenylate Cyclase Activity
Rhodopsin Mediated Signaling Pathway
Cytosolic Calcium Ion Homeostasis
Positive Regulation Of Vasoconstriction
Response To Peptide
Platelet Activation
Positive Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Blood Pressure
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Small GTPase Mediated Signal Transduction
Response To Wounding
Ras Protein Signal Transduction
Regulation Of Neuron Death
Axon Guidance
Regulation Of Cell Death
Axonogenesis
Axon Development
Cell Morphogenesis Involved In Neuron Differentiation
Chemotaxis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Intracellular Signal Transduction
Neuron Projection Morphogenesis
Cell Morphogenesis Involved In Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Neuron Projection Development
Positive Regulation Of Hair Follicle Cell Proliferation
Cell Projection Morphogenesis
Cell Part Morphogenesis
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Signal Transduction
Actin Filament Branching
Submandibular Salivary Gland Formation
Neuron Development
Platelet Activation
Signaling
Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Synapse Structural Plasticity
Cell Morphogenesis
Cell Communication
Leukocyte Migration
Positive Regulation Of Rac Protein Signal Transduction
Regulation Of Neuron Apoptotic Process
Neuron Differentiation
Cell Projection Organization
Establishment Of Golgi Localization
Fc Receptor Signaling Pathway
Transformed Cell Apoptotic Process
Positive Regulation Of Metalloenzyme Activity
Locomotion
Cellular Response To Peptide Hormone Stimulus
Neuron Fate Determination
Epithelial-mesenchymal Cell Signaling
Cellular Response To Stimulus
Muscle Cell Differentiation
Tagcloud
?
abcc4
abcc5
all97
atp6ap2
caucasian
childhood
cytotoxicity
frmd4b
genotyped
impdh1
itpa
kcnma1
lymphoblastic
lymphoblastoid
mercaptopurine
nme1
outside
shifts
slc28a3
snp
snps
tagsnps
thioguanine
thiopurine
thiopurines
top
uk
validation
xdh
Tagcloud (Difference)
?
abcc4
abcc5
all97
atp6ap2
caucasian
childhood
cytotoxicity
frmd4b
genotyped
impdh1
itpa
kcnma1
lymphoblastic
lymphoblastoid
mercaptopurine
nme1
outside
shifts
slc28a3
snp
snps
tagsnps
thioguanine
thiopurine
thiopurines
top
uk
validation
xdh
Tagcloud (Intersection)
?