GNG2 and AVPR2

Number of citations of the paper that reports this interaction (PMID 15782186)
67

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GNG2	AVPR2
Gene Name		guanine nucleotide binding protein (G protein), gamma 2	arginine vasopressin receptor 2
Image
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Signal Transducer Activity G-protein Beta-subunit Binding	Vasopressin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Water Transport Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity I-kappaB Kinase/NF-kappaB Signaling Excretion Hemostasis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Telencephalon Development Positive Regulation Of Protein Ubiquitination Interferon-gamma Production Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Negative Regulation Of Renal Sodium Excretion Positive Regulation Of Vasoconstriction Transmembrane Transport Response To Peptide
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Aquaporin-mediated transport GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors
Drugs		Halothane	Desmopressin Vasopressin Conivaptan Terlipressin Tolvaptan
Diseases
GWAS		Non-melanoma skin cancer ( 23548203)
Protein-Protein Interactions		15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R	7 interactors: ARRB2 AVP C1QTNF1 GNAS GNB1 GNG2 GRK5
Entrez ID		54331	554
HPRD ID		16234	02368
Ensembl ID		ENSG00000186469	ENSG00000126895
Uniprot IDs		P59768	P30518
PDB IDs		4KFM	4JQI
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure	Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Platelet Activation Regulation Of Body Fluid Levels Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Glucagon Response To Fatty Acid Generation Of Precursor Metabolites And Energy Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Acid Chemical Wound Healing Cytosolic Calcium Ion Homeostasis Regulation Of Signal Transduction Cell Activation Response To Wounding Renal Water Homeostasis Regulation Of Signaling Negative Regulation Of Mitochondrion Organization Response To Organonitrogen Compound Response To Lipid Chemical Homeostasis Response To Organic Cyclic Compound Cellular Calcium Ion Homeostasis Water Transport Energy Derivation By Oxidation Of Organic Compounds Calcium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus Response To Hormone Fluid Transport Cellular Response To Peptide Apoptotic Process Multicellular Organismal Water Homeostasis Programmed Cell Death Cell Death Death Water Homeostasis
Tagcloud ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
Tagcloud (Difference) ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
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