GNG2 and CACNA1H

Number of citations of the paper that reports this interaction (PMID 12853961)
23

Data Source:
HPRD (in vitro)

		GNG2	CACNA1H
Gene Name		guanine nucleotide binding protein (G protein), gamma 2	calcium channel, voltage-dependent, T type, alpha 1H subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Plasma Membrane Voltage-gated Calcium Channel Complex Caveola Integral Component Of Membrane Sarcolemma
	Molecular Function	Signal Transducer Activity G-protein Beta-subunit Binding	Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	Transport Muscle Contraction Axon Guidance Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Regulation Of Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Positive Regulation Of Acrosome Reaction
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs		Halothane	Isradipine Cinnarizine Zonisamide Felodipine Nitrendipine Nifedipine Amiodarone Bepridil Mibefradil Flunarizine
Diseases
GWAS		Non-melanoma skin cancer ( 23548203)
Protein-Protein Interactions		15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R	2 interactors: GNG2 KCNMA1
Entrez ID		54331	8912
HPRD ID		16234	07442
Ensembl ID		ENSG00000186469	ENSG00000196557
Uniprot IDs		P59768	B3KQH9 O95180
PDB IDs		4KFM
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure	Negative Regulation Of Cell Volume Smooth Muscle Contraction Involved In Micturition Response To Carbon Monoxide Blood Coagulation Hemostasis Micturition Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Cellular Potassium Ion Homeostasis Urinary Bladder Smooth Muscle Contraction Response To Wounding Cellular Response To Prostaglandin E Stimulus Potassium Ion Homeostasis Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cellular Response To Catecholamine Stimulus Cell Volume Homeostasis Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Cellular Response To Fatty Acid Excretion Response To Glucagon Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Smooth Muscle Contraction Response To Fatty Acid Response To Osmotic Stress Renal System Process Response To Calcium Ion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Acid Chemical Potassium Ion Transmembrane Transport Platelet Activation Potassium Ion Transport Muscle Contraction Response To Stress Muscle System Process
Tagcloud ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	altering arborization biophysical blocker burst c456s cav3 changing channels dendrites dendritic determinants electrical epilepsy ethosuximide excitability firing generalized goals idiopathic indirectly influences oscillations p2 rebound seizure substantially transactivator tta
Tagcloud (Difference) ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	altering arborization biophysical blocker burst c456s cav3 changing channels dendrites dendritic determinants electrical epilepsy ethosuximide excitability firing generalized goals idiopathic indirectly influences oscillations p2 rebound seizure substantially transactivator tta
Tagcloud (Intersection) ?