GNG2 and CHRM2

Number of citations of the paper that reports this interaction (PMID 9063897)
11

Data Source:
HPRD (in vivo)

		GNG2	CHRM2
Gene Name		guanine nucleotide binding protein (G protein), gamma 2	cholinergic receptor, muscarinic 2
Image
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Postsynaptic Membrane
	Molecular Function	Signal Transducer Activity G-protein Beta-subunit Binding	G-protein Coupled Acetylcholine Receptor Activity
	Biological Process	Energy Reserve Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Synaptic Transmission Blood Coagulation Cell Proliferation Platelet Activation Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Regulation Of Heart Contraction Response To Virus Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Halothane	Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Carbachol Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxacurium chloride Doxepin Flavoxate Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Fesoterodine Dimethindene Aclidinium
Diseases
GWAS		Non-melanoma skin cancer ( 23548203)	Heart rate ( 23583979)
Protein-Protein Interactions		15 interactors: ADRA2A ADRB2 AVPR2 BTK CACNA1H CHRM2 GNB1 GNB3 GNB4 GNB5 MRGPRX1 PGGT1B PLEKHG2 SMURF2 TBXA2R	9 interactors: GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 SAG SET
Entrez ID		54331	1129
HPRD ID		16234	00328
Ensembl ID		ENSG00000186469	ENSG00000181072
Uniprot IDs		P59768	A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1
PDB IDs		4KFM	1LUB 3UON
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Stimulus Cellular Response To Stimulus Signal Transduction Signaling Cell Communication Cellular Response To Hormone Stimulus Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Response To Glucagon Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Response To Hormone Regulation Of CAMP Biosynthetic Process Energy Derivation By Oxidation Of Organic Compounds Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Blood Circulation G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To External Stimulus Negative Regulation Of Muscle Contraction Generation Of Precursor Metabolites And Energy Homeostatic Process Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Hemostasis Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Muscle Contraction Chemical Homeostasis Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Positive Regulation Of Vasoconstriction Response To Peptide Platelet Activation Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Blood Pressure	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Dopamine Receptor Signaling Pathway Platelet Activation G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Tachykinin Receptor Signaling Pathway Signaling Negative Regulation Of Cell Death Protein Neddylation Cell Communication Regulation Of Cellular Process Regulation Of Melanocyte Differentiation Cellular Response To Prostaglandin E Stimulus Response To Redox State G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Response To PH Nucleosome Disassembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Receptor Catabolic Process Negative Regulation Of Histone Acetylation Cellular Response To Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Developmental Pigmentation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Protein Acetylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Apoptotic Process Endosome To Lysosome Transport Rhodopsin Mediated Signaling Pathway Regulation Of Cell Death
Tagcloud ?		abcc4 abcc5 all97 atp6ap2 caucasian childhood cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	adulthood amplitude auditory childhood cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual
Tagcloud (Difference) ?		abcc4 abcc5 all97 atp6ap2 caucasian cytotoxicity frmd4b genotyped impdh1 itpa kcnma1 lymphoblastic lymphoblastoid mercaptopurine nme1 outside shifts slc28a3 snp snps tagsnps thioguanine thiopurine thiopurines top uk validation xdh	adulthood amplitude auditory cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual
Tagcloud (Intersection) ?		childhood