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GNG2 and GNB5
Number of citations of the paper that reports this interaction (PMID
8636150
)
15
Data Source:
HPRD
(two hybrid)
GNG2
GNB5
Gene Name
guanine nucleotide binding protein (G protein), gamma 2
guanine nucleotide binding protein (G protein), beta 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Extracellular Vesicular Exosome
Nucleus
Plasma Membrane
Molecular Function
Signal Transducer Activity
G-protein Beta-subunit Binding
GTPase Activity
Signal Transducer Activity
Protein Binding
G-protein Gamma-subunit Binding
Chaperone Binding
Biological Process
Energy Reserve Metabolic Process
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Synaptic Transmission
Blood Coagulation
Cell Proliferation
Platelet Activation
Small Molecule Metabolic Process
Cellular Response To Glucagon Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Catecholamine Stimulus
Signal Transduction
Phototransduction, Visible Light
Metabolic Process
Rhodopsin Mediated Signaling Pathway
Regulation Of Rhodopsin Mediated Signaling Pathway
Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
G alpha (s) signalling events
Activation of GABAB receptors
Glucagon-type ligand receptors
G beta:gamma signalling through PLC beta
Signaling by Wnt
Metabolic disorders of biological oxidation enzymes
G protein gated Potassium channels
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
G alpha (z) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ADP signalling through P2Y purinoceptor 12
Glucagon signaling in metabolic regulation
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Inwardly rectifying K+ channels
G-protein beta:gamma signalling
Opioid Signalling
Activation of Kainate Receptors upon glutamate binding
Aquaporin-mediated transport
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (q) signalling events
GPCR downstream signaling
Platelet homeostasis
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
G alpha (q) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signal amplification
Potassium Channels
G beta:gamma signalling through PI3Kgamma
G alpha (12/13) signalling events
Class B/2 (Secretin family receptors)
Prostacyclin signalling through prostacyclin receptor
GABA B receptor activation
GABA receptor activation
Activation of G protein gated Potassium channels
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
GPCR ligand binding
beta-catenin independent WNT signaling
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Ca2+ pathway
G-protein activation
G alpha (q) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
G alpha (s) signalling events
Glucagon-type ligand receptors
Signal amplification
Signaling by Wnt
G beta:gamma signalling through PLC beta
Metabolic disorders of biological oxidation enzymes
G beta:gamma signalling through PI3Kgamma
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
G alpha (z) signalling events
G alpha (12/13) signalling events
G alpha (i) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Class B/2 (Secretin family receptors)
ADP signalling through P2Y purinoceptor 12
Prostacyclin signalling through prostacyclin receptor
G-protein beta:gamma signalling
Vasopressin regulates renal water homeostasis via Aquaporins
Opioid Signalling
Regulation of insulin secretion
Activation of Kainate Receptors upon glutamate binding
GPCR ligand binding
Aquaporin-mediated transport
beta-catenin independent WNT signaling
Adrenaline,noradrenaline inhibits insulin secretion
Thrombin signalling through proteinase activated receptors (PARs)
G alpha (q) signalling events
Presynaptic function of Kainate receptors
GPCR downstream signaling
Platelet homeostasis
Ca2+ pathway
G-protein activation
Platelet activation, signaling and aggregation
Transmission across Chemical Synapses
Drugs
Halothane
Diseases
GWAS
Non-melanoma skin cancer (
23548203
)
Protein-Protein Interactions
15 interactors:
ADRA2A
ADRB2
AVPR2
BTK
CACNA1H
CHRM2
GNB1
GNB3
GNB4
GNB5
MRGPRX1
PGGT1B
PLEKHG2
SMURF2
TBXA2R
26 interactors:
ANXA7
APP
BNIP3L
CDKN1A
CSNK2B
E2F2
EIF3J
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNGT1
MCM2
MVD
NR6A1
OLFM2
PSD
PSMD4
RGS11
RGS6
RGS7
RGS9
RPA1
TSC22D1
Entrez ID
54331
10681
HPRD ID
16234
09191
Ensembl ID
ENSG00000186469
ENSG00000069966
Uniprot IDs
P59768
B3KWS4
O14775
PDB IDs
4KFM
Enriched GO Terms of Interacting Partners
?
G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Response To Organic Substance
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Response To Stimulus
Cellular Response To Stimulus
Signal Transduction
Signaling
Cell Communication
Cellular Response To Hormone Stimulus
Energy Reserve Metabolic Process
Cellular Response To Glucagon Stimulus
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Regulation Of Blood Pressure
Regulation Of Smooth Muscle Contraction
Response To Glucagon
Cellular Response To Organic Substance
Regulation Of Adenylate Cyclase Activity
Regulation Of Vasoconstriction
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Regulation Of Cyclase Activity
Response To Hormone
Regulation Of CAMP Biosynthetic Process
Energy Derivation By Oxidation Of Organic Compounds
Regulation Of CAMP Metabolic Process
Regulation Of Cellular Process
Blood Circulation
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Negative Regulation Of Smooth Muscle Contraction
Adrenergic Receptor Signaling Pathway
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Response To External Stimulus
Negative Regulation Of Muscle Contraction
Generation Of Precursor Metabolites And Energy
Homeostatic Process
Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration
Hemostasis
Regulation Of Rhodopsin Mediated Signaling Pathway
Regulation Of Muscle Contraction
Chemical Homeostasis
Activation Of Adenylate Cyclase Activity
Rhodopsin Mediated Signaling Pathway
Cytosolic Calcium Ion Homeostasis
Positive Regulation Of Vasoconstriction
Response To Peptide
Platelet Activation
Positive Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Blood Pressure
Cellular Response To Glucagon Stimulus
Response To Glucagon
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Energy Reserve Metabolic Process
G-protein Coupled Receptor Signaling Pathway
Response To Hormone
Cellular Response To Stimulus
Signal Transduction
Cellular Response To Hormone Stimulus
Signaling
Cell Communication
Response To Stimulus
Regulation Of Cellular Process
Termination Of G-protein Coupled Receptor Signaling Pathway
Termination Of Signal Transduction
Energy Derivation By Oxidation Of Organic Compounds
Cell Surface Receptor Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Response To Organic Substance
Generation Of Precursor Metabolites And Energy
Response To Peptide Hormone
Cellular Response To Organonitrogen Compound
Response To Peptide
Regulation Of Signal Transduction
Cellular Response To Organic Substance
Regulation Of Catalytic Activity
Positive Regulation Of Catalytic Activity
Response To Organonitrogen Compound
G1/S Transition Of Mitotic Cell Cycle
Synaptic Transmission
Regulation Of Signaling
Mitotic Cell Cycle
Cellular Response To Light Stimulus
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Signal Transduction By P53 Class Mediator
Regulation Of Metabolic Process
Cell-cell Signaling
Regulation Of Rhodopsin Mediated Signaling Pathway
Positive Regulation Of Metabolic Process
Response To Light Stimulus
DNA Strand Elongation Involved In DNA Replication
Cellular Process
Cellular Response To Radiation
Apoptotic Process
DNA Strand Elongation
Small Molecule Metabolic Process
Rhodopsin Mediated Signaling Pathway
Tagcloud
?
abcc4
abcc5
all97
atp6ap2
caucasian
childhood
cytotoxicity
frmd4b
genotyped
impdh1
itpa
kcnma1
lymphoblastic
lymphoblastoid
mercaptopurine
nme1
outside
shifts
slc28a3
snp
snps
tagsnps
thioguanine
thiopurine
thiopurines
top
uk
validation
xdh
Tagcloud (Difference)
?
abcc4
abcc5
all97
atp6ap2
caucasian
childhood
cytotoxicity
frmd4b
genotyped
impdh1
itpa
kcnma1
lymphoblastic
lymphoblastoid
mercaptopurine
nme1
outside
shifts
slc28a3
snp
snps
tagsnps
thioguanine
thiopurine
thiopurines
top
uk
validation
xdh
Tagcloud (Intersection)
?