CHRM2 and GNA11

Number of citations of the paper that reports this interaction (PMID 7797501)
58

Data Source:
HPRD (in vivo)

		CHRM2	GNA11
Gene Name		cholinergic receptor, muscarinic 2	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Postsynaptic Membrane	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Acetylcholine Receptor Activity	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Regulation Of Heart Contraction Response To Virus Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway	Skeletal System Development Action Potential Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Heart Development Blood Coagulation Platelet Activation Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Carbachol Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxacurium chloride Doxepin Flavoxate Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Fesoterodine Dimethindene Aclidinium
Diseases
GWAS		Heart rate ( 23583979)
Protein-Protein Interactions		9 interactors: GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 SAG SET	17 interactors: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR
Entrez ID		1129	2767
HPRD ID		00328	00759
Ensembl ID		ENSG00000181072
Uniprot IDs		A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1	P29992
PDB IDs		1LUB 3UON
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Dopamine Receptor Signaling Pathway Platelet Activation G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Tachykinin Receptor Signaling Pathway Signaling Negative Regulation Of Cell Death Protein Neddylation Cell Communication Regulation Of Cellular Process Regulation Of Melanocyte Differentiation Cellular Response To Prostaglandin E Stimulus Response To Redox State G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Response To PH Nucleosome Disassembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Receptor Catabolic Process Negative Regulation Of Histone Acetylation Cellular Response To Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Developmental Pigmentation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Protein Acetylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Apoptotic Process Endosome To Lysosome Transport Rhodopsin Mediated Signaling Pathway Regulation Of Cell Death	G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Tube Size Vasoconstriction Regulation Of Phosphorus Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Blood Circulation Cytosolic Calcium Ion Homeostasis Ion Homeostasis Chemical Homeostasis Regulation Of MAPK Cascade Regulation Of Phosphorylation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Homeostatic Process Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Phosphorylation Signal Transduction Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Cellular Chemical Homeostasis Signaling Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Cellular Metal Ion Homeostasis Cellular Homeostasis Cellular Cation Homeostasis Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Ion Homeostasis Vascular Smooth Muscle Contraction Regulation Of Blood Pressure Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Abiotic Stimulus Regulation Of Signal Transduction Muscle Contraction Regulation Of CAMP Biosynthetic Process Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Response To Stimulus Endothelin Receptor Signaling Pathway
Tagcloud ?		adulthood amplitude auditory childhood cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual	amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina
Tagcloud (Difference) ?		adulthood amplitude auditory childhood cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual	amplifications backgroundendometrial cervix coexistent compatible conclusionsmolecular concurrently cul definite diagnose encourage endometrial extending fraumeni germline helps inversion jak3 massively mesothelioma ovaries peritoneal pik3ca pmm preoperatively presentationa sac urged vagina
Tagcloud (Intersection) ?