CHRM2 and TMEM8B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM2	TMEM8B
Description		cholinergic receptor muscarinic 2	transmembrane protein 8B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Golgi Apparatus Plasma Membrane Cilium Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Synapse Postsynaptic Membrane Presynapse Cholinergic Synapse	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Arrestin Family Protein Binding	Protein Binding
	Biological Process	Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Presynaptic Modulation Of Chemical Synaptic Transmission	Cell Adhesion Cell-matrix Adhesion Regulation Of Mitotic Cell Cycle
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Cisatracurium Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine Rapacuronium ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Dimetindene Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) PR interval ( 32439900) Pulse pressure ( 30224653) Resting heart rate ( 27798624 29769521)
Interacting Genes		18 interacting genes: GJC2 GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 HERPUD1 MDH1 RGS7 SAG SET SHISA4 SLC52A2 TMEM8B TSPAN33 TSPAN7	3 interacting genes: ATXN1L CHRM2 EZR
Entrez ID		1129	51754
HPRD ID		00328	16674
Ensembl ID		ENSG00000181072	ENSG00000137103
Uniprot IDs		A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1	A0A2R8Y2M5 A6NDV4
PDB IDs		3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK 6U1N 7T8X 7T90 7T94 7T96 8J8R 8J97 8JAF
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Phototransduction Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity Protein Phosphatase Inhibitor Activity 4-hydroxybutyrate Receptor Activity Postsynaptic Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Detection Of Light Stimulus Plasma Membrane G Protein-coupled Receptor Catabolic Process Photoreceptor Outer Segment	Cholinergic Synapse Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Arrestin Family Protein Binding Ciliary Basal Body Microvillus Organization Intestinal Hexose Absorption Terminal Web Assembly Cadherin Binding Protein Localization To Cell Cortex Positive Regulation Of Early Endosome To Late Endosome Transport Membrane To Membrane Docking Regulation Of Microvillus Length Intestinal D-glucose Absorption Positive Regulation Of Protein Localization To Early Endosome Establishment Of Centrosome Localization Microvillus Assembly Regulation Of Cell Projection Size Negative Regulation Of P38MAPK Cascade Cortical Microtubule Organization RNA Binding Astral Microtubule Organization POZ Domain Binding Positive Regulation Of Hematopoietic Stem Cell Proliferation Protein Kinase A Signaling Positive Regulation Of Protein Localization To Endosome Uropod Protein Kinase A Catalytic Subunit Binding S100 Protein Binding Sphingosine-1-phosphate Receptor Signaling Pathway Postsynaptic Actin Cytoskeleton Organization Sphingolipid Mediated Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Hematopoietic Stem Cell Proliferation Dendrite Regulation Of Early Endosome To Late Endosome Transport G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Microvillus Membrane Protein Kinase A Regulatory Subunit Binding Intestinal Absorption Establishment Of Apical/basal Cell Polarity Cortical Cytoskeleton Establishment Of Monopolar Cell Polarity Protein Kinase A Binding Gland Morphogenesis Establishment Of Epithelial Cell Polarity Filopodium Assembly
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