CHRM2 and MDH1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM2	MDH1
Description		cholinergic receptor muscarinic 2	malate dehydrogenase 1
Image
GO Annotations	Cellular Component	Nucleolus Golgi Apparatus Plasma Membrane Cilium Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Synapse Postsynaptic Membrane Presynapse Cholinergic Synapse	Extracellular Space Cytoplasm Centrosome Cytosol Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Arrestin Family Protein Binding	Catalytic Activity Malic Enzyme Activity Protein Binding Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity
	Biological Process	Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Presynaptic Modulation Of Chemical Synaptic Transmission	Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADP+ Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle
Pathways		Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Malate-aspartate shuttle
Drugs		Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Cisatracurium Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine Rapacuronium ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Dimetindene Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil	NADH Nicotinamide adenine dinucleotide phosphate Artenimol
Diseases
GWAS		Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) PR interval ( 32439900) Pulse pressure ( 30224653) Resting heart rate ( 27798624 29769521)	Asthma and attention deficit hyperactivity disorder ( 31619474) Blood protein levels ( 30072576) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		18 interacting genes: GJC2 GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 HERPUD1 MDH1 RGS7 SAG SET SHISA4 SLC52A2 TMEM8B TSPAN33 TSPAN7	15 interacting genes: CDC42 CHRM2 EGFR ERBB2 FUS GPD1 HSD17B10 HSPB2 LTB4R2 MPP3 SERPINB5 TERF1 TERF2IP TP53 TTC3
Entrez ID		1129	4190
HPRD ID		00328	01100
Ensembl ID		ENSG00000181072	ENSG00000014641
Uniprot IDs		A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1	A0A5K1VW95 P40925 V9HWF2
PDB IDs		3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK 6U1N 7T8X 7T90 7T94 7T96 8J8R 8J97 8JAF	7RM9 7RRL
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Phototransduction Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity Protein Phosphatase Inhibitor Activity 4-hydroxybutyrate Receptor Activity Postsynaptic Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Detection Of Light Stimulus Plasma Membrane G Protein-coupled Receptor Catabolic Process Photoreceptor Outer Segment	Negative Regulation Of Telomere Maintenance Shelterin Complex Regulation Of DNA Metabolic Process ERBB2-EGFR Signaling Pathway Nuclear Telomere Cap Complex Negative Regulation Of Chromosome Organization Telomere Capping G-rich Strand Telomeric DNA Binding Regulation Of Phosphorus Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase ERBB2 Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Regulation Of Epithelial Cell Proliferation Gland Morphogenesis Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Regulation Of Cell Growth Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Organelle Organization Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Multivesicular Body, Internal Vesicle Lumen Molecular Condensate Scaffold Activity Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cellular Response To Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Repair
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