CHRM2 and GNA15

Number of citations of the paper that reports this interaction (PMID 7797501)
58

Data Source:
HPRD (in vitro)

		CHRM2	GNA15
Gene Name		cholinergic receptor, muscarinic 2	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Postsynaptic Membrane	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	G-protein Coupled Acetylcholine Receptor Activity	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Regulation Of Heart Contraction Response To Virus Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Platelet Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Carbachol Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxacurium chloride Doxepin Flavoxate Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Fesoterodine Dimethindene Aclidinium
Diseases
GWAS		Heart rate ( 23583979)	Heart failure ( 20445134)
Protein-Protein Interactions		9 interactors: GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 SAG SET	19 interactors: ADRB2 ADRBK1 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		1129	2769
HPRD ID		00328	00760
Ensembl ID		ENSG00000181072	ENSG00000060558
Uniprot IDs		A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1	P30679
PDB IDs		1LUB 3UON
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Dopamine Receptor Signaling Pathway Platelet Activation G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Signal Transduction Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Tachykinin Receptor Signaling Pathway Signaling Negative Regulation Of Cell Death Protein Neddylation Cell Communication Regulation Of Cellular Process Regulation Of Melanocyte Differentiation Cellular Response To Prostaglandin E Stimulus Response To Redox State G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Response To PH Nucleosome Disassembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Receptor Catabolic Process Negative Regulation Of Histone Acetylation Cellular Response To Stimulus Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Developmental Pigmentation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Negative Regulation Of Protein Acetylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Apoptotic Process Endosome To Lysosome Transport Rhodopsin Mediated Signaling Pathway Regulation Of Cell Death	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Defense Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signaling Cell Communication Sensory Perception Of Pain Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Opioid Receptor Signaling Pathway Cellular Cation Homeostasis Cellular Response To Stimulus Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Phosphorus Metabolic Process Cellular Chemical Homeostasis Blood Circulation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Muscle Contraction Response To Stress Chemical Homeostasis Ion Homeostasis Synaptic Transmission Regulation Of Cyclase Activity Immune Response Regulation Of Phosphorylation Cytosolic Calcium Ion Homeostasis Regulation Of MAPK Cascade Regulation Of Catalytic Activity Homeostatic Process Regulation Of Signaling Interleukin-8-mediated Signaling Pathway Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Muscle Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP Biosynthetic Process Negative Regulation Of Lyase Activity Response To Stimulus Regulation Of CAMP Metabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Catalytic Activity
Tagcloud ?		adulthood amplitude auditory childhood cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual
Tagcloud (Difference) ?		adulthood amplitude auditory childhood cholinergic combining confirms dependence familial finds homozygous loading longitudinally modeling muscarinic odds offspring olds p300 predicts regardless rs1824024 slower substance trajectories trajectory tt variation visual
Tagcloud (Intersection) ?