HOXC9 and HOXC13

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		HOXC9	HOXC13
Gene Name		homeobox C9	homeobox C13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis	Hair Follicle Development Transcription, DNA-templated Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Nail Development Tongue Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Biliary atresia ( 20460270) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		16 interactors: CBX6 ELAVL2 GMNN GTF2A1L HOXC13 HOXD1 HOXD9 IRF9 LPXN NMI PCGF2 POLR2D POLR3D POU2F1 ZFP36 ZNF384	7 interactors: APEX1 ELF1 HNRNPAB HOXC9 MEIS1 NR2E3 RHOXF2
Entrez ID		3225	3229
HPRD ID		00857	00862
Ensembl ID		ENSG00000180806	ENSG00000123364
Uniprot IDs		P31274 Q8N561	P31276
PDB IDs		2LP0
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Skeletal System Development Regulation Of Cellular Process Cellular Metabolic Process Positive Regulation Of Gene Expression Organ Morphogenesis Transcription From RNA Polymerase III Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Anterior/posterior Pattern Specification Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex MRNA 3'-end Processing MRNA Export From Nucleus In Response To Heat Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Negative Regulation Of Cellular Metabolic Process RNA 3'-end Processing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Embryonic Skeletal System Morphogenesis Pattern Specification Process Negative Regulation Of B Cell Receptor Signaling Pathway Olfactory Placode Formation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cellular Metabolic Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Positive Regulation Of Rhodopsin Gene Expression Developmental Process Eye Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Rhodopsin Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Camera-type Eye Development Megakaryocyte Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Immune System Process Nucleotide-excision Repair, DNA Gap Filling Biosynthetic Process DNA Demethylation Negative Regulation Of Biosynthetic Process Cellular Response To Organic Cyclic Compound Eye Development Negative Regulation Of T Cell Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Organ Development Positive Regulation Of Cell Cycle G1/S Phase Transition Nuclear DNA Replication
Tagcloud ?		acquisition addressed attenuation chip coordinated coordinates differentiation diverse downregulation e2f6 exit global interacted mapping microarray neuroblastoma neuronal profiling promoters question recruited remarkably repressing repressor seq sets specialized upregulation wide	chip deep dysregulated dysregulation h3k27me3 homeobox hoxb7 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tshz3 tumorigenic
Tagcloud (Difference) ?		acquisition addressed attenuation coordinated coordinates differentiation diverse downregulation e2f6 exit global interacted mapping microarray neuroblastoma neuronal profiling promoters question recruited remarkably repressing repressor seq sets specialized upregulation wide	deep dysregulated dysregulation h3k27me3 homeobox hoxb7 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tshz3 tumorigenic
Tagcloud (Intersection) ?		chip