HOXC9 and ZFP36

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		HOXC9	ZFP36
Description		homeobox C9	ZFP36 ring finger protein
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Aggresome Transcription Repressor Complex	Exosome (RNase Complex) P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule CCR4-NOT Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding Heat Shock Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein-containing Complex Binding Metal Ion Binding RNA Polymerase Binding 14-3-3 Protein Binding Protein-RNA Sequence-specific Adaptor Activity
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Negative Regulation Of Cell Cycle Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Response To Wounding Regulation Of Keratinocyte Proliferation Regulatory NcRNA-mediated Gene Silencing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription MiRNA-mediated Gene Silencing By Inhibition Of Translation P38MAPK Cascade Response To Starvation Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation MRNA Transport Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Polynucleotide Adenylyltransferase Activity Positive Regulation Of Intracellular MRNA Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		A body shape index ( 34021172) Heel bone mineral density ( 30598549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		29 interacting genes: CBX6 CYSRT1 ELAVL2 GMNN GTF2A1L HOXC13 HOXD1 HOXD9 IRF9 KRTAP6-2 LPXN MAGED1 MSX2 NFKBID NMI PAX6 PAX8 PBX2 PCGF2 POLR2D POLR3D POU2AF1 POU2F1 SPMIP9 TLE5 UFSP1 ZFP36 ZMYND12 ZNF384	28 interacting genes: APP ATG16L1 CCDC85B CDK6 CXCL8 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 FHL3 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 PRMT2 RUNX1T1 SFN TNF UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		3225	7538
HPRD ID		00857	01835
Ensembl ID		ENSG00000180806	ENSG00000128016
Uniprot IDs		P31274	P26651
PDB IDs		2LP0 2MSY	4J8S
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regionalization Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Pattern Specification Process Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anterior/posterior Pattern Specification DNA-binding Transcription Factor Activity Chromatin Binding Animal Organ Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Embryonic Morphogenesis Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Embryonic Skeletal System Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal System Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Embryonic Limb Morphogenesis PRC1 Complex Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Catabolic Process Response To Cytokine RRNA Catabolic Process Response To Peptide Nucleus Response To External Biotic Stimulus Positive Regulation Of Leukocyte Migration Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Protein Kinase C Inhibitor Activity Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Gene Expression RNA Catabolic Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription Cytoplasm Nuclear RNA Surveillance Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Leukocyte Migration Positive Regulation Of Biosynthetic Process Cytosol Regulation Of Viral Life Cycle RNA Surveillance Phosphoserine Residue Binding Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Protein Sequestering Activity Regulation Of Translation
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