POLG and MARCHF5

Number of citations of the paper that reports this interaction (PubMedID 33657094)
51

Data Source:
BioGRID (enzymatic study)

		POLG	MARCHF5
Description		DNA polymerase gamma, catalytic subunit	membrane associated ring-CH-type finger 5
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Chromosome Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Lyase Activity DNA Polymerase Activity 5'-deoxyribose-5-phosphate Lyase Activity Catalytic Activity, Acting On A Nucleic Acid	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Replication Proofreading DNA Biosynthetic Process	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		5 interacting genes: MARCHF5 RBM11 SSBP1 TTC3 USP30	43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A
Entrez ID		5428	54708
HPRD ID		01438	07909
Ensembl ID		ENSG00000140521	ENSG00000198060
Uniprot IDs		E5KNU5 P54098	Q9NX47
PDB IDs		3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5D 8V5R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Regulation Of Mitochondrion Organization Protein K48-linked Ubiquitination Peroxisomal Membrane Regulation Of Mitochondrial DNA Replication Protein K6-linked Deubiquitination Post-translational Protein Modification Regulation Of Mitochondrial DNA Metabolic Process Mitochondrial Outer Membrane Macromolecule Metabolic Process Positive Regulation Of CGAS/STING Signaling Pathway Protein Polyubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Mitophagy	Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination
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