POLG and SSBP1

Number of citations of the paper that reports this interaction (PubMedID 10827171)
0

Data Source:
HPRD (in vivo)

		POLG	SSBP1
Description		DNA polymerase gamma, catalytic subunit	single stranded DNA binding protein 1
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GO Annotations	Cellular Component	Mitochondrial Chromosome Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome
	Molecular Function	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Lyase Activity DNA Polymerase Activity 5'-deoxyribose-5-phosphate Lyase Activity Catalytic Activity, Acting On A Nucleic Acid	DNA Binding Chromatin Binding Single-stranded DNA Binding RNA Binding Protein Binding Enzyme Activator Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Replication Proofreading DNA Biosynthetic Process	DNA Replication DNA-templated DNA Replication Positive Regulation Of Helicase Activity Protein Homotetramerization Positive Regulation Of Mitochondrial DNA Replication
Pathways		Strand-asynchronous mitochondrial DNA replication	Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Anorexia nervosa ( 23568457)
Interacting Genes		5 interacting genes: MARCHF5 RBM11 SSBP1 TTC3 USP30	13 interacting genes: CDK1 CEBPA CKS1B CKS2 FOXP1 GCM2 LDB1 LGALS7 LGALS7B OTUD6A POLG TP53 YWHAQ
Entrez ID		5428	6742
HPRD ID		01438	02703
Ensembl ID		ENSG00000140521	ENSG00000106028
Uniprot IDs		E5KNU5 P54098	A4D1U3 B7Z268 Q04837
PDB IDs		3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5D 8V5R	1S3O 2DUD 3ULL 6RUP 8UZT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Regulation Of Mitochondrion Organization Protein K48-linked Ubiquitination Peroxisomal Membrane Regulation Of Mitochondrial DNA Replication Protein K6-linked Deubiquitination Post-translational Protein Modification Regulation Of Mitochondrial DNA Metabolic Process Mitochondrial Outer Membrane Macromolecule Metabolic Process Positive Regulation Of CGAS/STING Signaling Pathway Protein Polyubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Mitophagy	Chromatin Binding Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleobase-containing Compound Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Mitochondrial DNA Metabolic Process Core Promoter Sequence-specific DNA Binding Negative Regulation Of Stem Cell Proliferation DNA-templated Transcription Protein-containing Complex Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity 14-3-3 Protein Binding Regulation Of RNA Metabolic Process Pronuclear Fusion Mitotic DNA-templated DNA Replication Regulation Of DNA-templated Transcription Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cell Differentiation Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Mitotic DNA Integrity Checkpoint Signaling Cyclin B1-CDK1 Complex Macromolecule Biosynthetic Process Cell Population Proliferation Cyclin A1-CDK1 Complex Regulation Of Heart Growth DNA-templated DNA Replication DNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Cyclin A2-CDK1 Complex Cyclin-dependent Protein Kinase Activity Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Transcription Regulator Complex Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Stem Cell Proliferation Regulation Of Stem Cell Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mononuclear Cell Differentiation Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Response To Vitamin B2 C/EBP Complex SCF Ubiquitin Ligase Complex DNA Replication Proofreading
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