POLG

Description		DNA polymerase gamma, catalytic subunit
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GO Annotations	Cellular Component	Mitochondrial Chromosome Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid
	Molecular Function	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Lyase Activity DNA Polymerase Activity 5'-deoxyribose-5-phosphate Lyase Activity Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Replication Proofreading DNA Biosynthetic Process
Pathways		Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		5 interacting genes: MARCHF5 RBM11 SSBP1 TTC3 USP30
Entrez ID		5428
HPRD ID		01438
Ensembl ID		ENSG00000140521
Uniprot IDs		E5KNU5 P54098
PDB IDs		3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5D 8V5R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Regulation Of Mitochondrion Organization Protein K48-linked Ubiquitination Peroxisomal Membrane Regulation Of Mitochondrial DNA Replication Protein K6-linked Deubiquitination Post-translational Protein Modification Regulation Of Mitochondrial DNA Metabolic Process Mitochondrial Outer Membrane Macromolecule Metabolic Process Positive Regulation Of CGAS/STING Signaling Pathway Protein Polyubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Mitophagy
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