POLG and USP30

Number of citations of the paper that reports this interaction (PubMedID 33657094)
51

Data Source:
BioGRID (enzymatic study)

		POLG	USP30
Description		DNA polymerase gamma, catalytic subunit	ubiquitin specific peptidase 30
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GO Annotations	Cellular Component	Mitochondrial Chromosome Mitochondrion Mitochondrial Matrix Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid	Nucleus Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Lyase Activity DNA Polymerase Activity 5'-deoxyribose-5-phosphate Lyase Activity Catalytic Activity, Acting On A Nucleic Acid	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	DNA Metabolic Process DNA Replication DNA-templated DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Replication Proofreading DNA Biosynthetic Process	Autophagy Of Mitochondrion Pexophagy Proteolysis Mitochondrial Fusion Protein Deubiquitination Regulation Of Protein Stability Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Negative Regulation Of Mitophagy
Pathways		Strand-asynchronous mitochondrial DNA replication	Ub-specific processing proteases Pexophagy
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		5 interacting genes: MARCHF5 RBM11 SSBP1 TTC3 USP30	6 interacting genes: PAICS POLG PRKN RHBDD2 UBB UBC
Entrez ID		5428	84749
HPRD ID		01438	15633
Ensembl ID		ENSG00000140521	ENSG00000135093
Uniprot IDs		E5KNU5 P54098	B3KUS5 Q70CQ3
PDB IDs		3IKM 4ZTU 4ZTZ 5C51 5C52 5C53 8D33 8D37 8D3R 8D42 8G5I 8G5J 8G5K 8G5L 8G5M 8G5N 8G5O 8G5P 8T7E 8UDK 8UDL 8V54 8V55 8V5D 8V5R	5OHK 5OHN 5OHP 8D0A 8D1T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Regulation Of Mitochondrion Organization Protein K48-linked Ubiquitination Peroxisomal Membrane Regulation Of Mitochondrial DNA Replication Protein K6-linked Deubiquitination Post-translational Protein Modification Regulation Of Mitochondrial DNA Metabolic Process Mitochondrial Outer Membrane Macromolecule Metabolic Process Positive Regulation Of CGAS/STING Signaling Pathway Protein Polyubiquitination Protein K11-linked Deubiquitination Negative Regulation Of Mitophagy	Protein Tag Activity Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Protein Ubiquitination Negative Regulation Of Intralumenal Vesicle Formation Modification-dependent Protein Catabolic Process Regulation Of Mitochondrial Membrane Potential Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin ERAD Pathway Positive Regulation Of Protein Ubiquitination Mitochondrion Localization Proteolysis Macromolecule Catabolic Process Mitochondrion Regulation Of Signal Transduction By P53 Class Mediator DNA Replication Proofreading Mitochondrial Chromosome Gamma DNA Polymerase Complex Endocytic Vesicle Membrane Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Phosphoribosylaminoimidazole Carboxylase Activity Protein Modification By Small Protein Conjugation Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To L-glutamine Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Lyase Activity Lewy Body Regulation Of Spontaneous Synaptic Transmission Regulation Of Proteasomal Protein Catabolic Process Type 2 Mitophagy Post-translational Protein Modification Regulation Of Protein Ubiquitination
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