PYGL

Gene Name		phosphorylase, glycogen, liver
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Purine Nucleobase Binding ATP Binding Glucose Binding Drug Binding Glycogen Phosphorylase Activity AMP Binding Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Protein Homodimerization Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Pathogenesis Glucose Homeostasis Small Molecule Metabolic Process Necroptotic Process
Pathways		Glucose metabolism Glycogen breakdown (glycogenolysis) Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs		Pyridoxal Phosphate Adenosine monophosphate 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione CP-526423 1-N-Acetyl-Beta-D-Glucosamine Beta-D-Glucose 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate Phosphonoserine 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid N-(2-CHLORO-4-FLUOROBENZOYL)-N\'-(5-HYDROXY-2-METHOXYPHENYL)UREA
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406)
Protein-protein Interactions		4 interactors: BAG1 HSD3B7 IDH2 PYGB
Entrez ID		5836
HPRD ID		01987
Ensembl ID		ENSG00000100504
Uniprot IDs		P06737
PDB IDs		1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW
Enriched GO Terms of Interacting Partners?		Glyoxylate Cycle Negative Regulation Of Motor Neuron Apoptotic Process Cellular Carbohydrate Metabolic Process Chaperone Cofactor-dependent Protein Refolding Energy Derivation By Oxidation Of Organic Compounds Oxidation-reduction Process Isocitrate Metabolic Process Glyoxylate Metabolic Process Generation Of Precursor Metabolites And Energy 2-oxoglutarate Metabolic Process Glycogen Catabolic Process Monocarboxylic Acid Metabolic Process Protein Refolding Small Molecule Metabolic Process Polysaccharide Catabolic Process Bile Acid Biosynthetic Process Cellular Carbohydrate Catabolic Process Bile Acid Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Glycogen Metabolic Process Aerobic Respiration Positive Regulation Of Neuron Apoptotic Process Chaperone-mediated Protein Folding Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Protein Localization To Mitochondrion Positive Regulation Of Neuron Death Cellular Aldehyde Metabolic Process Organic Acid Metabolic Process
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