PYGL and PYGM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PYGL	PYGM
Description		glycogen phosphorylase L	glycogen phosphorylase, muscle associated
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Purine Nucleobase Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding ATP Binding D-glucose Binding Glycogen Phosphorylase Activity AMP Binding Transferase Activity Glycosyltransferase Activity Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding	Nucleotide Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Glycogen Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Response To Bacterium Glucose Homeostasis Necroptotic Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis)
Drugs			Pyridoxal phosphate Beta-D-Glucopyranose Spirohydantoin (5S,7R,8S,9S,10R)-3-Amino-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione alpha-D-glucose 6-phosphate N-beta-D-glucopyranosylacetamide Monofluorophosphate ion Beta-D-Glucose 3,8,9,10-tetrahydroxy-7-hydroxymethyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione Nojirimycine Tetrazole Indirubin-5-sulphonate 2-Deoxy-Glucose-6-Phosphate C-(1-hydrogyl-beta-D-glucopyranosyl) formamide alpha-D-glucopyranosyl-2-carboxylic acid amide alpha-D-glucose-1-phosphate 8,9,10-Trihydroxy-7-hydroxymethyl-2-thioxo-6-oxa-1,3-diaza-spiro[4.5]decan-4-one 4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole N-acetyl-N'-beta-D-glucopyranosyl urea 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole CP-320626 (3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester 8,9,10-trihydroxy-7-hydroxymethyl-3-methyl-6-oxa-1,3-diaza-spiro[4.5]decane-2,4-dione Alvocidib 1-deoxy-1-methoxycarbamido-beta-D-glucopyranose N-[(5S,7R,8S,9S,10R)-8,9,10-Trihydroxy-7-(hydroxymethyl)-2,4-dioxo-6-oxa-1,3-diazaspiro[4.5]dec-3-yl]acetamide 1-Deoxy-1-methoxycarbamido-beta-D-gluco-2-heptulopyranosonamide 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid 2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium N(6)-(pyridoxal phosphate)-L-lysine Heptulose-2-Phosphate N-(Benzoylcarbamoyl)-beta-D-glucopyranosylamine Dexfosfoserine 1-Deoxy-1-acetylamino-beta-D-gluco-2-heptulopyranosonamide Inosinic Acid 7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID 4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID 4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL ({[(3E)-2'-Oxo-2',7'-dihydro-2,3'-biindol-3(7H)-ylidene]amino}oxy)acetic acid (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 30072576) Psychosis (atypical) ( 24132900) Rectal cancer ( 33632709)	Urate levels ( 21768215)
Interacting Genes		7 interacting genes: BAG1 CEBPA HSD17B10 HSD3B7 IDH2 PYGB PYGM	28 interacting genes: AGTPBP1 ARID1B CDC42BPB CLASP2 DNM2 FAM110A IGBP1 INTS4 LMNA NIPSNAP2 NTAQ1 PDE4DIP POMP PPP1CA PPP1R3B PPP2CA PRKAB2 PYGL S100A1 SGCG SRP72 TOP1 TRAPPC2 TRIM54 TRIM55 TRIM63 TTN WWP1
Entrez ID		5836	5837
HPRD ID		01987	01986
Ensembl ID		ENSG00000100504	ENSG00000068976
Uniprot IDs		P06737	P11217
PDB IDs		1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW 8EMS	1Z8D
Enriched GO Terms of Interacting Partners?		Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Bile Acid Biosynthetic Process Polysaccharide Catabolic Process Glycogen Catabolic Process Bile Acid Metabolic Process Steroid Metabolic Process Generation Of Precursor Metabolites And Energy RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Pyridoxal Phosphate Binding Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity Carbohydrate Metabolic Process Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Glyoxylate Cycle Isocitrate Dehydrogenase (NADP+) Activity Monocarboxylic Acid Metabolic Process CHOP-C/EBP Complex Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Carbohydrate Catabolic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Oxidoreductase Activity White Fat Cell Proliferation Mitochondrial RNA 5'-end Processing Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Isoleucine Metabolic Process L-isoleucine Catabolic Process Isocitrate Metabolic Process Epsilon DNA Polymerase Complex B Cell Chemotaxis Small Molecule Metabolic Process TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity	RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cortical Microtubule Plus-end Regulation Of Carbohydrate Catabolic Process M Band Cytoplasm Regulation Of Microtubule Polymerization Or Depolymerization Glycogen Granule Regulation Of Microtubule-based Process Regulation Of Glycogen Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Z Disc Glycogen Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Microtubule Energy Reserve Metabolic Process Protein Phosphatase Type 1 Complex Polysaccharide Metabolic Process Cytosol Microtubule-based Process Positive Regulation Of Glycogen Biosynthetic Process INTAC Complex Microtubule Organizing Center Organization Response To Lead Ion Negative Regulation Of Glycolytic Process RNA Polymerase II Transcription Initiation Surveillance Organelle Organization Protein Phosphatase 1 Binding Negative Regulation Of ATP Metabolic Process I Band Actomyosin Structure Organization Establishment Of Organelle Localization Regulation Of Glycogen Biosynthetic Process Cytoskeleton Organization Protein Modification Process Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Microtubule Depolymerization RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Phosphoprotein Phosphatase Activity Nuclear RNA Surveillance Regulation Of Microtubule Depolymerization Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Membrane Tubulation Centrosome Cycle Vesicle Scission Cytoskeleton Positive Regulation Of High Voltage-gated Calcium Channel Activity Protein Phosphatase Regulator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?