PYGL and IDH2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PYGL	IDH2
Gene Name		phosphorylase, glycogen, liver	isocitrate dehydrogenase 2 (NADP+), mitochondrial
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Extracellular Vesicular Exosome
	Molecular Function	Purine Nucleobase Binding ATP Binding Glucose Binding Drug Binding Glycogen Phosphorylase Activity AMP Binding Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Protein Homodimerization Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity NAD Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Pathogenesis Glucose Homeostasis Small Molecule Metabolic Process Necroptotic Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Glucose metabolism Glycogen breakdown (glycogenolysis) Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs		Pyridoxal Phosphate Adenosine monophosphate 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione CP-526423 1-N-Acetyl-Beta-D-Glucosamine Beta-D-Glucose 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate Phosphonoserine 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid N-(2-CHLORO-4-FLUOROBENZOYL)-N\'-(5-HYDROXY-2-METHOXYPHENYL)UREA
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406)
Protein-Protein Interactions		4 interactors: BAG1 HSD3B7 IDH2 PYGB	2 interactors: PYGL SLC2A4
Entrez ID		5836	3418
HPRD ID		01987	00973
Ensembl ID		ENSG00000100504	ENSG00000182054
Uniprot IDs		P06737	B4DFL2 B4DSZ6 P48735
PDB IDs		1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW	4JA8
Enriched GO Terms of Interacting Partners?		Glyoxylate Cycle Negative Regulation Of Motor Neuron Apoptotic Process Cellular Carbohydrate Metabolic Process Chaperone Cofactor-dependent Protein Refolding Energy Derivation By Oxidation Of Organic Compounds Oxidation-reduction Process Isocitrate Metabolic Process Glyoxylate Metabolic Process Generation Of Precursor Metabolites And Energy 2-oxoglutarate Metabolic Process Glycogen Catabolic Process Monocarboxylic Acid Metabolic Process Protein Refolding Small Molecule Metabolic Process Polysaccharide Catabolic Process Bile Acid Biosynthetic Process Cellular Carbohydrate Catabolic Process Bile Acid Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Glycogen Metabolic Process Aerobic Respiration Positive Regulation Of Neuron Apoptotic Process Chaperone-mediated Protein Folding Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Protein Localization To Mitochondrion Positive Regulation Of Neuron Death Cellular Aldehyde Metabolic Process Organic Acid Metabolic Process	Glucose Homeostasis Pathogenesis Amylopectin Biosynthetic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Glucose Import Chemical Homeostasis Glycogen Catabolic Process Polysaccharide Catabolic Process Carbohydrate Metabolic Process Hexose Transmembrane Transport Cellular Response To Osmotic Stress Cellular Carbohydrate Catabolic Process Necroptotic Process Homeostatic Process Brown Fat Cell Differentiation Programmed Necrotic Cell Death Necrotic Cell Death Carbohydrate Transmembrane Transport Glycogen Metabolic Process Glucose Transport Hexose Transport Polysaccharide Metabolic Process Response To Osmotic Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Small Molecule Metabolic Process Carbohydrate Transport Fat Cell Differentiation Energy Reserve Metabolic Process Response To Ethanol Glucose Metabolic Process Carbohydrate Catabolic Process Ribose Phosphate Biosynthetic Process Hexose Metabolic Process Cellular Response To Insulin Stimulus Cellular Carbohydrate Metabolic Process Monosaccharide Metabolic Process Response To Insulin Response To Hypoxia Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Ribose Phosphate Metabolic Process Cellular Response To Peptide
Tagcloud ?		coater crystallized degassing depositing diaphragm evacuated evaporable evaporated evaporation film glu glutamic handmade intramolecular lactamization molten particulates periodic preserving pyroglutamic quartz racemization resonator simply soldering spacing thin vacuum versatile	abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider
Tagcloud (Difference) ?		coater crystallized degassing depositing diaphragm evacuated evaporable evaporated evaporation film glu glutamic handmade intramolecular lactamization molten particulates periodic preserving pyroglutamic quartz racemization resonator simply soldering spacing thin vacuum versatile	abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider
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