PYGL and HSD3B7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PYGL	HSD3B7
Description		glycogen phosphorylase L	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	Nucleotide Binding Purine Nucleobase Binding Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding ATP Binding D-glucose Binding Glycogen Phosphorylase Activity AMP Binding Transferase Activity Glycosyltransferase Activity Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding	3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Response To Bacterium Glucose Homeostasis Necroptotic Process	Lipid Metabolic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process B Cell Chemotaxis
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4) Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 30072576) Psychosis (atypical) ( 24132900) Rectal cancer ( 33632709)
Interacting Genes		7 interacting genes: BAG1 CEBPA HSD17B10 HSD3B7 IDH2 PYGB PYGM	56 interacting genes: ADAMTSL4 AGR2 ANAPC11 APPBP2 ARID5A ASB12 BTN2A2 C22orf39 COMT CREB5 CYSRT1 DAPP1 EFEMP1 EFEMP2 EGFL7 ELOVL4 EMG1 FBLN2 GLRX3 HOXA1 HSD17B13 ICAM1 KPNA4 KPRP KRT31 KRT40 KRT86 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-2 KRTAP4-2 KRTAP5-9 LCE4A LINGO1 MEI4 MEOX2 MGAT5B NOTCH2NLA NR4A3 OTX2 PYGL RBP3 REEP4 RGS17 SPRY2 SSC4D TMEM31 TRIM42 YPEL3 ZBTB42 ZNF655
Entrez ID		5836	80270
HPRD ID		01987	09680
Ensembl ID		ENSG00000100504	ENSG00000099377
Uniprot IDs		P06737	Q9H2F3
PDB IDs		1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW 8EMS
Enriched GO Terms of Interacting Partners?		Glycogen Phosphorylase Activity 1,4-alpha-oligoglucan Phosphorylase Activity Bile Acid Biosynthetic Process Polysaccharide Catabolic Process Glycogen Catabolic Process Bile Acid Metabolic Process Steroid Metabolic Process Generation Of Precursor Metabolites And Energy RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Pyridoxal Phosphate Binding Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity Carbohydrate Metabolic Process Response To Vitamin B2 C/EBP Complex 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Glyoxylate Cycle Isocitrate Dehydrogenase (NADP+) Activity Monocarboxylic Acid Metabolic Process CHOP-C/EBP Complex Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Carbohydrate Catabolic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Oxidoreductase Activity White Fat Cell Proliferation Mitochondrial RNA 5'-end Processing Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Isoleucine Metabolic Process L-isoleucine Catabolic Process Isocitrate Metabolic Process Epsilon DNA Polymerase Complex B Cell Chemotaxis Small Molecule Metabolic Process TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Epidermis Development Dopamine Secretion Epidermal Growth Factor Receptor Binding
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