PYGL and BAG1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PYGL	BAG1
Gene Name		phosphorylase, glycogen, liver	BCL2-associated athanogene
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Purine Nucleobase Binding ATP Binding Glucose Binding Drug Binding Glycogen Phosphorylase Activity AMP Binding Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Protein Homodimerization Activity	Receptor Signaling Protein Activity Protein Binding Chaperone Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Glucose Metabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Pathogenesis Glucose Homeostasis Small Molecule Metabolic Process Necroptotic Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Chaperone Cofactor-dependent Protein Refolding
Pathways		Glucose metabolism Glycogen breakdown (glycogenolysis) Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs		Pyridoxal Phosphate Adenosine monophosphate 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione CP-526423 1-N-Acetyl-Beta-D-Glucosamine Beta-D-Glucose 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate Phosphonoserine 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid N-(2-CHLORO-4-FLUOROBENZOYL)-N\'-(5-HYDROXY-2-METHOXYPHENYL)UREA
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406)
Protein-Protein Interactions		4 interactors: BAG1 HSD3B7 IDH2 PYGB	26 interactors: AR ARRB1 BCL2 BCL2L1 ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 MAPT MET NR3C1 PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 VDR
Entrez ID		5836	573
HPRD ID		01987	03292
Ensembl ID		ENSG00000100504	ENSG00000107262
Uniprot IDs		P06737	Q99933
PDB IDs		1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW	1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z
Enriched GO Terms of Interacting Partners?		Glyoxylate Cycle Negative Regulation Of Motor Neuron Apoptotic Process Cellular Carbohydrate Metabolic Process Chaperone Cofactor-dependent Protein Refolding Energy Derivation By Oxidation Of Organic Compounds Oxidation-reduction Process Isocitrate Metabolic Process Glyoxylate Metabolic Process Generation Of Precursor Metabolites And Energy 2-oxoglutarate Metabolic Process Glycogen Catabolic Process Monocarboxylic Acid Metabolic Process Protein Refolding Small Molecule Metabolic Process Polysaccharide Catabolic Process Bile Acid Biosynthetic Process Cellular Carbohydrate Catabolic Process Bile Acid Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Glycogen Metabolic Process Aerobic Respiration Positive Regulation Of Neuron Apoptotic Process Chaperone-mediated Protein Folding Carboxylic Acid Metabolic Process Carbohydrate Metabolic Process Protein Localization To Mitochondrion Positive Regulation Of Neuron Death Cellular Aldehyde Metabolic Process Organic Acid Metabolic Process	Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Signaling Regulation Of Signaling Intracellular Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Unfolded Protein Negative Regulation Of Cellular Protein Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Proliferation Signaling Positive Regulation Of Catalytic Activity Cell Communication Gland Development Anatomical Structure Morphogenesis Regulation Of Cellular Ketone Metabolic Process Signal Transduction Steroid Hormone Mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Viral Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Protein Ubiquitination Response To External Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		coater crystallized degassing depositing diaphragm evacuated evaporable evaporated evaporation film glu glutamic handmade intramolecular lactamization molten particulates periodic preserving pyroglutamic quartz racemization resonator simply soldering spacing thin vacuum versatile	bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		coater crystallized degassing depositing diaphragm evacuated evaporable evaporated evaporation film glu glutamic handmade intramolecular lactamization molten particulates periodic preserving pyroglutamic quartz racemization resonator simply soldering spacing thin vacuum versatile	bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?